Tìm theo
Mafenide
Các tên gọi khác (4 ) :
  • 4-(aminomethyl)benzenesulfonamide
  • 4-Homosufanilamide
  • Bensulfamide
  • Maphenidum
Thuốc Gốc
Small Molecule
CAS: 138-39-6
CTHH: C7H10N2O2S
PTK: 186.232
Mafenide is a sulfonamide-type medication used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C7H10N2O2S
Phân tử khối
186.232
Monoisotopic mass
186.046298264
InChI
InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
InChI Key
InChIKey=TYMRLRRVMHJFTF-UHFFFAOYSA-N
IUPAC Name
4-(aminomethyl)benzene-1-sulfonamide
Traditional IUPAC Name
emilene
SMILES
NCC1=CC=C(C=C1)S(N)(=O)=O
Độ tan chảy
177
Độ hòa tan
5.18e+00 g/l
logP
-0.54
logS
-1.6
pKa (strongest acidic)
10.27
pKa (Strongest Basic)
9.24
PSA
86.18 Å2
Refractivity
46.69 m3·mol-1
Polarizability
18.24 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : Mafenide is a sulfonamide-type medication used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns.
Dược Động Học :
▧ Absorption :
Mafenide is absorbed through devascularized areas into the systemic circulation following topical administration.
▧ Metabolism :
Metabolized to a carbonic anhydrase inhibitor.
▧ Route of Elimination :
Renal—Metabolite rapidly excreted in urine in high concentrations; however, the parent compound has not been detected in urine.
Độc Tính : Since mafenide is metabolized to a carbonic anhydrase inhibitor, metabolic acidosis could occur. Mafenide is contraindicated in persons with renal impairment or sulfonamide hypersensitivity.
Chỉ Định : Mafenide is indicated in the treatment of severe burns.
Liều Lượng & Cách Dùng : Powder, for solution - Topical - 5% topical solution (50g packets for reconstitution in 1000mL of sterile water)
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Mylan
    Sản phẩm biệt dược : Sulfamylon
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06795
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02351
Wikipedia
http://en.wikipedia.org/wiki/Mafenide
Drugs.com
http://www.drugs.com/international/Mafenide.html
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