Tìm theo
Lysergic Acid Diethylamide
Các tên gọi khác (23 ) :
  • (+)-LSD
  • (+)-lysergic acid diethylamide
  • 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide
  • D-LSD
  • D-LSD-25
  • D-lysergic acid dethylamide
  • D-lysergic acid diethylamide
  • D-lysergic acid n,n-diethylamide
  • Dextrolysergic acid diethylamide
  • Diethylamid kyseliny lysergove
  • LSD
  • LSD-25
  • Lysergamid
  • Lysergamide
  • Lysergaure diethylamid
  • Lysergic acid amide
  • Lysergic acid diethylamide-25
  • Lysergide
  • Lysergidum
  • n,n-diethyl-(+)-lysergamide
  • N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide
  • N,n-diethyl-d-lysergamide
  • N,n-diethyllysergamide
serotonin antagonists, hallucinogens, serotonin receptor agonists
Thuốc Gốc
Small Molecule
CAS: 50-37-3
CTHH: C20H25N3O
PTK: 323.432
Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD on brain chemistry, and varies according to the susceptibility of the individual to the disorder. Many emotionally intense experiences can lead to flashbacks when a person is reminded acutely of the original experience. However, not all published case reports of chronic flashbacks appear to describe an anxious hyper-vigilant state reminiscent of post-traumatic stress disorder.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H25N3O
Phân tử khối
323.432
Monoisotopic mass
323.199762437
InChI
InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1
InChI Key
InChIKey=VAYOSLLFUXYJDT-RDTXWAMCSA-N
IUPAC Name
(4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide
Traditional IUPAC Name
cupcakes
SMILES
[H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N(CC)CC
Độ tan chảy
82.5 °C
Độ hòa tan
2.70e-01 g/l
logP
2.95
logS
-3.1
pKa (strongest acidic)
17.02
pKa (Strongest Basic)
7.98
PSA
39.34 Å2
Refractivity
98.73 m3·mol-1
Polarizability
37.54 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
7.8
Dược Động Học :
▧ Absorption :
Rapidly absorbed.
▧ Metabolism :
Hepatic.
▧ Half Life :
3 hours
Độc Tính : Estimates for the lethal dosage (LD50) of LSD range from 200 µg/kg to more than 1 mg/kg of human body mass, though most sources report that there are no known human cases of such an overdose.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04829
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5761
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506397
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07542
ChemSpider
http://www.chemspider.com/Chemical-Structure.5558.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21342
Wikipedia
http://en.wikipedia.org/wiki/Lysergic_acid_diethylamide
... loading
... loading