Tìm theo
LYM-2
Thuốc Gốc
Small Molecule
Lym-2 is an Iodine 131 radiolabled monoclonal antibody manufactured by Peregrine Pharmaceuticals (formerly Techniclone). It's use is targeted at B-cell non-Hodgkin's lymphoma patients. It is currently in Phase III clinical trials. Lym-2 produces murine IgGl monoclonal antibodies specifically against normal human B cells and derived malignancies. The Lym-2 antibodies have possible clinical utility for the in vivo diagnosis of human B-cell lymphomas and leukemias.
Cơ Chế Tác Dụng : Lym-2 is an Iodine 131 radiolabled monoclonal antibody manufactured by Peregrine Pharmaceuticals (formerly Techniclone). It's use is targeted at B-cell non-Hodgkin's lymphoma patients. It is currently in Phase III clinical trials. Lym-2 produces murine IgGl monoclonal antibodies specifically against normal human B cells and derived malignancies. The Lym-2 antibodies have possible clinical utility for the in vivo diagnosis of human B-cell lymphomas and leukemias. Lym-2 (Oncolym) is an antibody with a radioactive substance attached. The drug attaches to a protein found only on the surface of B lymphocytes such as cancerous B-cells found in many forms of Non-Hodgkin's lymphoma. The radioactivity targets the B-cell, destroying it. The specific B-cell surface marker the antibody attaches to is the HLA-Dr10 protein, a cell surface marker present on over 80% of lymphoma cells. Only about 2% of the normal blood cell population have B-cells that express the HLA-Dr10 marker. This means that Oncolym may selectively target lymphoma cancer cells and may spare healthy B-cells that are responsible for making antibodies that fight infection.
Chỉ Định : Investigated for use/treatment in lymphoma (non-hodgkin's).
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Oncolym
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drugbank
http://www.drugbank.ca/drugs/DB05788
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