Lunesta
Thuốc an thần
Biệt Dược
Nồng độ :
LUNESTA is available in 1 mg, 2 mg and 3 mg strengths for oral administration
Thành Phần Hoạt Chất
(1) :
LUNESTA is available in 1 mg, 2 mg and 3 mg strengths for oral administration. LUNESTA 3 mg tablets are round, dark blue, film-coated, and identified with debossed markings of S193 on one side. LUNESTA 2 mg tablets are round, white, film-coated, and identified with debossed markings of S191 on one side. LUNESTA 1 mg tablets are round, light blue, film-coated, and identified with debossed markings of S190 on one side
learn more at :
http://www.lunesta.com/pdf/PostedApprovedLabelingText.pdf
http://www.lunesta.com/pdf/lunesta-patient-medication-guide.pdf
Chỉ Định :
Lunesta® (eszopiclone) is a prescription sleep medicine used in adults for the treatment of a sleep problem called insomnia. Symptoms of insomnia include trouble falling asleep and waking up often during the night.
Chống Chỉ Định :
LUNESTA is contraindicated in patients with known hypersensitivity to eszopiclone. Hypersensitivity reactions include anaphylaxis and angioedema
Thận Trọng/Cảnh Báo :
Do not take more LUNESTA than prescribed. LUNESTA acts quickly, so take it right before bed, and only if you have 7-8 hours to devote to sleep. Do not take LUNESTA if you are allergic to anything in it. LUNESTA should not be taken together with alcohol or other sedative hypnotics. The morning after you take LUNESTA your ability to drive safely and think clearly may be decreased. Until you know how you will react to LUNESTA, you should not drive or perform other activities that require complete mental alertness the day after use. Call your doctor if your insomnia worsens or is not better within 7 to 10 days. This may mean that there is another condition causing your sleep problems. LUNESTA may cause serious side effects that you may not know are happening to you including daytime sleepiness, not thinking clearly, acting strangely, confused or upset, or walking, eating, driving or engaging in other activities while asleep. Other abnormal behaviors include aggressiveness, agitation, hallucinations and confusion. In depressed patients, worsening of depression including risk of suicide may occur. These risks may increase if you drink alcohol. Severe allergic reactions such as swelling of the tongue and throat occur rarely and may be fatal. Call your doctor if you experience these or any effects or reactions that concern you. LUNESTA, like most sleep medicines, carries some risk of dependency. Side effects may include unpleasant taste, headache, morning drowsiness and dizziness.
What is the most important information I should know about LUNESTA? Do not take more LUNESTA than prescribed. Do not take LUNESTA unless you are able to stay in bed a full night (7 to 8 hours) before you must be active again. Take LUNESTA right before you get in bed, not sooner. LUNESTA may cause serious side effects that you may not know are happening to you. These side effects include: sleepiness during the day not thinking clearly act strangely, confused, or upset "sleep-walking" or doing other activities when you are asleep like: o eating o talking o having sex o driving a car Call your healthcare provider right away if you find out that you have done any of the above activities after taking LUNESTA. The morning after you take LUNESTA your ability to drive safely and think clearly may be decreased. Do not take LUNESTA if you: drank alcohol that evening or before bed take other medicines that can make you sleepy. Talk to your doctor about all of your medicines. Your doctor will tell you if you can take LUNESTA with your other medicines. cannot get a full night’s sleep
What is the most important information I should know about LUNESTA? Do not take more LUNESTA than prescribed. Do not take LUNESTA unless you are able to stay in bed a full night (7 to 8 hours) before you must be active again. Take LUNESTA right before you get in bed, not sooner. LUNESTA may cause serious side effects that you may not know are happening to you. These side effects include: sleepiness during the day not thinking clearly act strangely, confused, or upset "sleep-walking" or doing other activities when you are asleep like: o eating o talking o having sex o driving a car Call your healthcare provider right away if you find out that you have done any of the above activities after taking LUNESTA. The morning after you take LUNESTA your ability to drive safely and think clearly may be decreased. Do not take LUNESTA if you: drank alcohol that evening or before bed take other medicines that can make you sleepy. Talk to your doctor about all of your medicines. Your doctor will tell you if you can take LUNESTA with your other medicines. cannot get a full night’s sleep
Hiệu Ứng Phụ/Tác Dụng Ngoại Ý :
What are the possible side effects of LUNESTA? Possible serious side effects of LUNESTA include: getting out of bed while not being fully awake and do an activity that you do not know you are doing. (See “What is the most important information I should know about LUNESTA?”) abnormal thoughts and behavior. Symptoms include more outgoing or aggressive behavior than normal, confusion, agitation, hallucinations, worsening of depression, and suicidal thoughts or actions. memory loss anxiety severe allergic reactions. Symptoms include swelling of the tongue or throat, trouble breathing, and nausea and vomiting. Get emergency medical help if you get these symptoms after taking LUNESTA. Call your doctor right away if you have any of the above side effects or any other side effects that worry you while using LUNESTA. The most common side effects of LUNESTA are: unpleasant taste in mouth, dry mouth drowsiness dizziness headache symptoms of the common cold You may still feel drowsy the next day after taking LUNESTA. Do not drive or do other dangerous activities after taking LUNESTA until you feel fully awake.
Liều Lượng & Cách Dùng :
The clinical trials performed in support of efficacy were up to 6 months in duration. The final formal assessments of sleep latency and maintenance were performed at 4 weeks in the 6-week study (adults only), at the end of both 2-week studies (elderly only) and at the end of the 6-month study (adults only)
Use the lowest effective dose for the patient.
DOSAGE AND ADMINISTRATION :
Use the lowest effective dose for the patient.
Dosage in Adults :
The recommended starting dose is 1 mg. Dosing can be raised to 2 mg or 3 mg if clinically indicated. In some patients, the higher morning blood levels of LUNESTA following use of the 2 mg or 3 mg dose increase the risk of next day impairment of driving and other activities that require full alertness .
The total dose of LUNESTA should not exceed 3 mg, once daily immediately before bedtime
Geriatric or Debilitated Patients : The total dose of LUNESTA should not exceed 2 mg in elderly or debilitated patients.
Patients with Severe Hepatic Impairment, or Taking Potent CYP3A4 Inhibitors In patients with severe hepatic impairment, or in patients coadministered LUNESTA with potent CYP3A4 inhibitors, the total dose of LUNESTA should not exceed 2 mg .
Use with CNS Depressants Dosage adjustments may be necessary when LUNESTA is combined with other CNS depressant drugs because of the potentially additive effects .
Administration with Food Taking LUNESTA with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of LUNESTA on sleep latency .
How should I take LUNESTA? Take LUNESTA exactly as prescribed. Do not take more LUNESTA than prescribed for you. Take LUNESTA right before you get into bed. 3 Do not take LUNESTA with or right after a meal. Do not take LUNESTA unless you are able to get a full night’s sleep before you must be active again. Call your doctor if your insomnia worsens or is not better within 7 to 10 days. This may mean that there is another condition causing your sleep problems. If you take too much LUNESTA or overdose, call your doctor or poison control center right away, or get emergency treatment.
Use the lowest effective dose for the patient.
DOSAGE AND ADMINISTRATION :
Use the lowest effective dose for the patient.
Dosage in Adults :
The recommended starting dose is 1 mg. Dosing can be raised to 2 mg or 3 mg if clinically indicated. In some patients, the higher morning blood levels of LUNESTA following use of the 2 mg or 3 mg dose increase the risk of next day impairment of driving and other activities that require full alertness .
The total dose of LUNESTA should not exceed 3 mg, once daily immediately before bedtime
Geriatric or Debilitated Patients : The total dose of LUNESTA should not exceed 2 mg in elderly or debilitated patients.
Patients with Severe Hepatic Impairment, or Taking Potent CYP3A4 Inhibitors In patients with severe hepatic impairment, or in patients coadministered LUNESTA with potent CYP3A4 inhibitors, the total dose of LUNESTA should not exceed 2 mg .
Use with CNS Depressants Dosage adjustments may be necessary when LUNESTA is combined with other CNS depressant drugs because of the potentially additive effects .
Administration with Food Taking LUNESTA with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of LUNESTA on sleep latency .
How should I take LUNESTA? Take LUNESTA exactly as prescribed. Do not take more LUNESTA than prescribed for you. Take LUNESTA right before you get into bed. 3 Do not take LUNESTA with or right after a meal. Do not take LUNESTA unless you are able to get a full night’s sleep before you must be active again. Call your doctor if your insomnia worsens or is not better within 7 to 10 days. This may mean that there is another condition causing your sleep problems. If you take too much LUNESTA or overdose, call your doctor or poison control center right away, or get emergency treatment.
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