Tìm theo
Lucanthone
Các tên gọi khác (6 ) :
  • 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one
  • 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one
  • 1-diethylaminoethylethylamino-4-methyl-thioxanthenone
  • Lucanthone
  • Lucanthonum
  • Lucantona
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 479-50-5
CTHH: C20H24N2OS
PTK: 340.482
One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H24N2OS
Phân tử khối
340.482
Monoisotopic mass
340.16093409
InChI
InChI=1S/C20H24N2OS/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20/h6-11,21H,4-5,12-13H2,1-3H3
InChI Key
InChIKey=FBQPGGIHOFZRGH-UHFFFAOYSA-N
IUPAC Name
1-{[2-(diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one
Traditional IUPAC Name
lucanthone
SMILES
CCN(CC)CCNC1=C2C(=O)C3=CC=CC=C3SC2=C(C)C=C1
Độ hòa tan
3.15e-03 g/l
logP
5.02
logS
-5
pKa (strongest acidic)
18.84
pKa (Strongest Basic)
8.69
PSA
32.34 Å2
Refractivity
106.01 m3·mol-1
Polarizability
39.6 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Although lucanthone has structural and biochemical similarities to Actinomycin D, it has no hematological or gastro-intestinal toxicity at clinically tolerated doses. In trials, Lucanthone was found to be safe, practical and effective and was proposed for use in clinical protocols for the treatment of cancer. The specificity of lucanthone in combination with radiation for the treatment of brain tumors arises from the fact that lucanthone acts preferentially on cycling cells (most of the normal brain cells are non-cycling) and the fact that lucanthone crosses the blood brain barrier efficiently.
Cơ Chế Tác Dụng : One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer. Recent data suggests that lucanthone inhibits post-radiation DNA repair in tumor cells. The ability of lucanthone to inhibit AP endonuclease and topoisomerase II probably account for the specific DNA repair inhibition in irradiated cells.
Dược Động Học :
▧ Absorption :
Orally available
Chỉ Định : Intended for use as a radiation sensitizer in the treatment of brain cancer.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Miracil D
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04967
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10180
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507260
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C11715
ChemSpider
http://www.chemspider.com/Chemical-Structure.9772.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748783
Wikipedia
http://en.wikipedia.org/wiki/Lucanthone
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