Tìm theo
Loracarbef
Các tên gọi khác (2) :
  • Loracarbef
  • Loracarbefum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 76470-66-1
ATC: J01DC08
ĐG : Dispensing Solutions , http://www.drxdispensing.com
CTHH: C16H16ClN3O4
PTK: 349.769
Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H16ClN3O4
Phân tử khối
349.769
Monoisotopic mass
349.082933722
InChI
InChI=1S/C16H16ClN3O4/c17-9-6-7-10-12(15(22)20(10)13(9)16(23)24)19-14(21)11(18)8-4-2-1-3-5-8/h1-5,10-12H,6-7,18H2,(H,19,21)(H,23,24)/t10-,11-,12+/m1/s1
InChI Key
InChIKey=JAPHQRWPEGVNBT-UTUOFQBUSA-N
IUPAC Name
(6R,7S)-7-[(2R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
loracarbef
SMILES
N[C@@H](C(=O)N[C@H]1[C@H]2CCC(Cl)=C(N2C1=O)C(O)=O)C1=CC=CC=C1
Độ hòa tan
3.25e-01 g/l
logP
0.5
logS
-3
pKa (strongest acidic)
3.13
pKa (Strongest Basic)
7.44
PSA
112.73 Å2
Refractivity
86.64 m3·mol-1
Polarizability
32.61 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Loracarbef is considered a second generation cephalosporin antibiotic. The advantages of cephalosporin antibiotics include a broad range of activity, a safe record in children with almost no dose-related toxicity, and the lack of need to monitor levels. Adverse reactions are rare and consist primarily of hypersensitivity reactions with urticaria, nonspecific rash, and pruritus. Loracarbef can be used to treat a large number of bacterial infections caused by gram-negative and gram-positive bacteria, including upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus, S. saprphyticus, S. penumoniae, H. influenzae and M. catarrhalis.
Cơ Chế Tác Dụng : Loracarbef is a carbacephem antibiotic sometimes grouped together with the second-generation cephalosporin antibiotics. It is marketed under the trade name Lorabid. Loracarbef is an oral, synthetic beta-lactam antibiotic of the carbacephem class. Chemically, carbacephems differ from cephalosporin-class antibiotics in the dihydrothiazine ring where a methylene group has been substituted for a sulfur atom. Loracarbef has a spectrum of activity similar to that of the second generation cephalosporins. It is structurally identical to cefaclor except for a sulfur atom that has been replaced by a methylene group. This change gives greater chemical stability in solution and allows storage at room temperature. Loracarbef, like all b-lactams and cephalosporins, inhibits penicillin binding proteins, enzymes that create the cross-linkage of the peptidoglycan polymer. This binding leads to interference with the formation and remodeling of the cell wall structure.
Dược Động Học :
▧ Absorption :
Well absorbed with approximately 90% absorbed from the gastrointestinal tract after oral ingestion.
▧ Protein binding :
25%
▧ Metabolism :
There is no evidence of metabolism in humans.
▧ Half Life :
1 hour. In subjects with moderate impairment of renal function the plasma half-life was prolonged to approximately 5.6 hours.
Độc Tính : Adverse effects include diarrhea, nausea, stomach upset, vomiting, headache, dizziness, rash, bone marrow depression.
Chỉ Định : Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus, S. saprphyticus, S. penumoniae, H. influenzae and M. catarrhalis.
Tương Tác Thuốc :
  • Probenecid Probenecid may increase the serum level of loracarbef.
Liều Lượng & Cách Dùng : Capsule - Oral
Powder, for suspension - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Actavis
    Sản phẩm biệt dược : Lorabid
  • Công ty : Pierre Fabre
    Sản phẩm biệt dược : Lorafem
  • Công ty : Lilly
    Sản phẩm biệt dược : Lorbef
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00447
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08109
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00916
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/61570-170-01
PharmGKB
http://www.pharmgkb.org/drug/PA164754806
Wikipedia
http://en.wikipedia.org/wiki/Loracarbef
RxList
http://www.rxlist.com/cgi/generic/loracarb.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/lor1237.shtml
Drugs.com
http://www.drugs.com/cdi/loracarbef.html
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