Tìm theo
Lisuride
Các tên gọi khác (5 ) :
  • Lisurid
  • Lisurida
  • Lisuride
  • Lisuridum
  • N'-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethylurea
Thuốc chống Parkinson
Thuốc Gốc
Small Molecule
CAS: 18016-80-3
ATC: G02CB02, N02CA07
CTHH: C20H26N4O
PTK: 338.4466
An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists). [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H26N4O
Phân tử khối
338.4466
Monoisotopic mass
338.210661474
InChI
InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1
InChI Key
InChIKey=BKRGVLQUQGGVSM-KBXCAEBGSA-N
IUPAC Name
3,3-diethyl-1-[(4S,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaen-4-yl]urea
Traditional IUPAC Name
lisuride
SMILES
[H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@@H](CN2C)NC(=O)N(CC)CC
Độ hòa tan
1.40e-01 g/l
logP
2.2
logS
-3.4
pKa (strongest acidic)
15.36
pKa (Strongest Basic)
6.88
PSA
51.37 Å2
Refractivity
101.81 m3·mol-1
Polarizability
38.81 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : An ergot derivative that acts as an agonist at dopamine D2 receptors (dopamine agonists). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (serotonin agonists). [PubChem] Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor. Lisuride is also used to lower prolactin and, in low doses, to prevent migraine attacks.
Dược Động Học :

▧ Protein binding :
about 15%
Chỉ Định : For the management of Parkinson's Disease
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Lisapharm
    Sản phẩm biệt dược : Arolac
  • Công ty : Bayer
    Sản phẩm biệt dược : Dipergon
  • Công ty : Bayer
    Sản phẩm biệt dược : Dopergin
  • Công ty : Bayer Santé
    Sản phẩm biệt dược : Dopergine
  • Công ty :
    Sản phẩm biệt dược : Proclacam
  • Công ty :
    Sản phẩm biệt dược : Revanil
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00589
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=28864
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505557
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D08132
ChemSpider
http://www.chemspider.com/Chemical-Structure.26847.html
PharmGKB
http://www.pharmgkb.org/drug/PA164749019
Wikipedia
http://en.wikipedia.org/wiki/Lisuride
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