Tìm theo
Lipoic Acid
Các tên gọi khác (20 ) :
  • 1,2-dithiolane-3-pentanoic acid
  • 1,2-dithiolane-3-valeric acid
  • 5-(1,2-dithiolan-3-yl)valeric acid
  • 5-(dithiolan-3-yl)valeric acid
  • 5-[3-(1,2-dithiolanyl)]pentanoic acid
  • 6-thioctic acid
  • 6-thiotic acid
  • 6,8-thioctic acid
  • 6,8-thiotic acid
  • Acetate-replacing factor
  • alpha-Lipoic acid
  • alpha-Liponsaeure
  • Biletan
  • Lipoic acid
  • liponic acid
  • Thioctansaeure
  • Thioctic acid
  • Thioctsaeure
  • Thioktsaeure
  • α-lipoic acid
Vitamin
Thuốc Gốc
Small Molecule
CAS: 62-46-4
ATC: A16AX01
ĐG : Freeda Vitamins , http://www.freedavitamins.com
CTHH: C8H14O2S2
PTK: 206.326
A vitamin-like antioxidant. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H14O2S2
Phân tử khối
206.326
Monoisotopic mass
206.043521072
InChI
InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
InChI Key
InChIKey=AGBQKNBQESQNJD-UHFFFAOYSA-N
IUPAC Name
5-(1,2-dithiolan-3-yl)pentanoic acid
Traditional IUPAC Name
thioctic acid dl-form
SMILES
OC(=O)CCCCC1CCSS1
Độ tan chảy
60.5 °C
Độ sôi
162.5 °C
Độ hòa tan
Insoluble
logP
2.1
logS
-3
pKa (strongest acidic)
4.52
PSA
37.3 Å2
Refractivity
54.37 m3·mol-1
Polarizability
22 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Lipoic acid (or α-lipoic acid) is able to pass the blood-brain barrier and is putatively used for detoxification of mercury attached to the brain cells. It can mobilise bound mercury into the blood stream as it is a mercaptan (sulfur compound which readily binds to the mercury). In the blood stream, another chelator such as dimercaptosuccinic acid (DMSA) or methylsulfonylmethane (MSM) is used to transfer mercury safely into the urine for excretion. Neither DMSA nor MSM can cross the blood-brain barrier, which is why both lipoic acid and DMSA are used. It is hypothesized that this treatment-along with carnitine, dimethylglycine (DMG), Vitamin B6, folic acid, and magnesium—could be used to treat autism and amalgam poisoning. In this hypothesis, the reason why autism is difficult to treat is that mercury is attached to the brain cells and most medicines and vitamin supplements do not penetrate the blood-brain barrier. However, α-lipoic acid and perhaps vitamin B12 could making it possible for other chelators to remove mercury safely out of the body and could perhaps one day be used as a treatment for autism. Because lipoic acid is related to cellular uptake of glucose and it is both soluble in water and fat, it is being used for treatment in diabetes. It may be helpful for people with Alzheimer's disease or Parkinson's disease.
Cơ Chế Tác Dụng : A vitamin-like antioxidant. [PubChem] Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. Some recent studies have suggested that the S-enantiomer in fact has an inhibiting effect on the R-enantiomer, reducing its biological activity substantially and actually adding to oxidative stress rather than reducing it. Furthermore, the S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity.
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Biletan
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00166
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00725
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00086
PharmGKB
http://www.pharmgkb.org/drug/PA164776929
Wikipedia
http://en.wikipedia.org/wiki/Lipoic_Acid
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