Tìm theo
Lintitript
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 136381-85-6
CTHH: C20H14ClN3O3S
PTK: 411.861
Lintitript is a new, highly specific and potent CCK-A receptor antagonist.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H14ClN3O3S
Phân tử khối
411.861
Monoisotopic mass
411.044439726
InChI
InChI=1S/C20H14ClN3O3S/c21-14-7-3-2-6-13(14)15-11-28-20(22-15)23-19(27)17-9-12-5-1-4-8-16(12)24(17)10-18(25)26/h1-9,11H,10H2,(H,25,26)(H,22,23,27)
InChI Key
InChIKey=ILNRQFBVVQUOLP-UHFFFAOYSA-N
IUPAC Name
2-(2-{[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl}-1H-indol-1-yl)acetic acid
Traditional IUPAC Name
(2-{[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl}indol-1-yl)acetic acid
SMILES
OC(=O)CN1C(=CC2=CC=CC=C12)C(=O)NC1=NC(=CS1)C1=CC=CC=C1Cl
Độ hòa tan
8.54e-03 g/l
logP
4.77
logS
-4.7
pKa (strongest acidic)
4.19
pKa (Strongest Basic)
-1.2
PSA
84.22 Å2
Refractivity
107.79 m3·mol-1
Polarizability
39.75 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Lintitript SR 27897 is a selective cholecystokinin type A (CCK-A) receptor antagonist. In February 2000, Sanofi announced that it was halting development of the drug for appetite disorders, and in September 2002, Sanofi announced that it had stopped investigation all together.
Cơ Chế Tác Dụng : Lintitript is a new, highly specific and potent CCK-A receptor antagonist. Cholecystokinin (CCK) modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. Lintitript antagonizes the effect of cholecystokinin by binding to the cholecystokinin type A (CCK-A) receptor. This action presumably alters feeding habits, however the exact mechanism of action is not known.
Chỉ Định : For the treatment of pancreatic cancer and appetite disorders.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04867
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=122077
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10239927
ChemSpider
http://www.chemspider.com/Chemical-Structure.108883.html
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