Tìm theo
lidocaine patch
Thuốc gây tê, mê
Thuốc Gốc
Small Molecule
CTHH: C14H22N2O
PTK: 234.3373
The lidocaine patch is composed of an adhesive material containing 5% lidocaine that is applied to a polyester felt backing. When it is applied to the skin, lidocaine is released into the epidermal and dermal layers of the skin, reducing pain at the site of the dysfunctional nerves damaged by the prior herpes zoster infection. The lidocaine patch provides pain reduction without numbness of the affected skin.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H22N2O
Phân tử khối
234.3373
Monoisotopic mass
234.173213336
InChI
InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
InChI Key
InChIKey=NNJVILVZKWQKPM-UHFFFAOYSA-N
IUPAC Name
2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
Traditional IUPAC Name
lidocaine
SMILES
CCN(CC)CC(=O)NC1=C(C)C=CC=C1C
Độ hòa tan
5.93e-01 g/l
logP
2.84
logS
-2.6
pKa (strongest acidic)
13.78
pKa (Strongest Basic)
7.75
PSA
32.34 Å2
Refractivity
73.93 m3·mol-1
Polarizability
27.77 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : The lidocaine patch is composed of an adhesive material containing 5% lidocaine that is applied to a polyester felt backing. When it is applied to the skin, lidocaine is released into the epidermal and dermal layers of the skin, reducing pain at the site of the dysfunctional nerves damaged by the prior herpes zoster infection. The lidocaine patch provides pain reduction without numbness of the affected skin. The lidocaine patch relieves pain and discomfort by blocking signals sent to nerve endings in the skin. Almost 20% of the one million Americans who develop shingles yearly experience long-term pain after the infection has resolved. People over age 60 are especially prone to postherpetic neuralgia.
Chỉ Định : Investigated for use/treatment in pain (acute or chronic).
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : LidoPain SP
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05291
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3676
ChemSpider
http://www.chemspider.com/Chemical-Structure.3548.html
Wikipedia
http://en.wikipedia.org/wiki/Lidoderm
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