Tìm theo
Licofelone
Các tên gọi khác (2) :
  • LCF
  • ML3000
Thuốc Gốc
Small Molecule
CAS: 156897-06-2
CTHH: C23H22ClNO2
PTK: 379.879
Developed by the German pharmaceutical company, Merckle GmbH, together with EuroAlliance partners Alfa Wassermann and Lacer, licofelone (ML3000) is a dual COX/LOX inhibitor and the first member of this new class of analgesic and anti-inflammatory drugs. It is currently under evaluation as a treatment for osteoarthritis (OA), the most common form of arthritis. Although phase III trials have been successfully completed in OA patients no dates for regulatory submission have yet been given.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H22ClNO2
Phân tử khối
379.879
Monoisotopic mass
379.13390666
InChI
InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27)
InChI Key
InChIKey=UAWXGRJVZSAUSZ-UHFFFAOYSA-N
IUPAC Name
2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
Traditional IUPAC Name
licofelone
SMILES
CC1(C)CN2C(CC(O)=O)=C(C(=C2C1)C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Độ hòa tan
1.11e-03 g/l
logP
5.72
logS
-5.5
pKa (strongest acidic)
4.83
PSA
42.23 Å2
Refractivity
108.79 m3·mol-1
Polarizability
41.8 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
4
Bioavailability
1
Dược Lực Học : Licofelone belongs to a novel class of dual-acting anti-inflammatory drugs called COX/LO inhibitors. This group of drugs simultaneously inhibits the enzymes cyclooxygenase (COX) and 5-lipoxygenase (LO).
Cơ Chế Tác Dụng : Developed by the German pharmaceutical company, Merckle GmbH, together with EuroAlliance partners Alfa Wassermann and Lacer, licofelone (ML3000) is a dual COX/LOX inhibitor and the first member of this new class of analgesic and anti-inflammatory drugs. It is currently under evaluation as a treatment for osteoarthritis (OA), the most common form of arthritis. Although phase III trials have been successfully completed in OA patients no dates for regulatory submission have yet been given. Licofelone, through combined 5-LOX/COX-inhibition, reduces levels of inflammatory prostaglandins and leukotrienes.
Chỉ Định : For the management of osteoarthritis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04725
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=133021
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10243273
ChemSpider
http://www.chemspider.com/Chemical-Structure.117391.html
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