Tìm theo
LGD2941
Thuốc Gốc
Small Molecule
CTHH: C17H16F6N2O2
PTK: 394.3116
LGD2941 is a non-steroidal, selective androgen receptor modulator (SARM) developed jointly by Ligand and TAP.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H16F6N2O2
Phân tử khối
394.3116
Monoisotopic mass
394.111596996
InChI
InChI=1S/C17H16F6N2O2/c1-8-2-5-13(15(27)17(21,22)23)25(8)9-3-4-12-10(6-9)11(16(18,19)20)7-14(26)24-12/h3-4,6-8,13,15,27H,2,5H2,1H3,(H,24,26)/t8-,13-,15-/m1/s1
InChI Key
InChIKey=HWLLYFXDDGGHOE-BCSUUIJWSA-N
IUPAC Name
6-[(2R,5R)-2-methyl-5-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-4-(trifluoromethyl)-1,2-dihydroquinolin-2-one
Traditional IUPAC Name
6-[(2R,5R)-2-methyl-5-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-4-(trifluoromethyl)-1H-quinolin-2-one
SMILES
C[C@@H]1CC[C@H]([C@@H](O)C(F)(F)F)N1C1=CC2=C(NC(=O)C=C2C(F)(F)F)C=C1
Độ hòa tan
3.44e-02 g/l
logP
3.58
logS
-4.1
pKa (strongest acidic)
10.91
pKa (Strongest Basic)
0.46
PSA
52.57 Å2
Refractivity
87.96 m3·mol-1
Polarizability
32.59 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : LGD2941 is a non-steroidal, selective androgen receptor modulator (SARM). SARMs are a novel class of non-steroidal, orally active molecules that selectively modulate the activity of the androgen receptor (AR) in different tissues, providing a wide range of opportunities for the treatment of many diseases and disorders with large patient populations in both men and women. Tissue-selective AR agonists or antagonists may provide utility in male hormone therapy and the treatment of patients with male hypogonadism, female and male osteoporosis, male and female sexual dysfunction, frailty, prostate cancer, hirsutism, acne, androgenetic alopecia and other diseases.
Cơ Chế Tác Dụng : LGD2941 is a non-steroidal, selective androgen receptor modulator (SARM) developed jointly by Ligand and TAP. LGD2941 selectively modulates the activity of the androgen receptor (AR) in different tissues.
Dược Động Học :
▧ Absorption :
Orally-available
Chỉ Định : For the treatment and prevention of osteoporosis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05234
ChemSpider
http://www.chemspider.com/Chemical-Structure.24694857.html
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