Tìm theo
Levonordefrin
Các tên gọi khác (5 ) :
  • alpha-Methylnoradrenaline
  • alpha-methylnorepinephrine
  • Corbadrine
  • Neo-cobefrin
  • α-methylnorepinephrine
Thuốc Gốc
Small Molecule
CAS: 829-74-3
CTHH: C9H13NO3
PTK: 183.2044
Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H13NO3
Phân tử khối
183.2044
Monoisotopic mass
183.089543287
InChI
InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1
InChI Key
InChIKey=GEFQWZLICWMTKF-CDUCUWFYSA-N
IUPAC Name
4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol
Traditional IUPAC Name
levonordefrin
SMILES
C[C@H](N)[C@H](O)C1=CC(O)=C(O)C=C1
Độ hòa tan
1.46e+01 g/l
logP
-0.39
logS
-1.1
pKa (strongest acidic)
9.63
pKa (Strongest Basic)
8.96
PSA
86.71 Å2
Refractivity
48.87 m3·mol-1
Polarizability
18.81 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : is a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions. It has pharmacologic activity similar to that of Epinephrine but it is more stable than Epinephrine. In equal concentrations, Levonordefrin is less potent than Epinephrine in raising blood pressure, and as a vasoconstrictor.
Cơ Chế Tác Dụng : Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It is designed to mimic the molecular shape of adrenaline. It binds to alpha-adrenergic receptors in the nasal mucosa. Here it can, therefore, cause vasoconstriction
Chỉ Định : Used as a topical nasal decongestant and vasoconstrictor in dentistry.
Tương Tác Thuốc :
  • Desvenlafaxine Desvenlafaxine may increase the tachycardic and vasopressor effects of levonordefrin. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Neo-Cobefrin
  • Công ty :
    Sản phẩm biệt dược : Nordefrin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06707
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=164739
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443259
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029048
PharmGKB
http://www.pharmgkb.org/drug/PA165958380
Wikipedia
http://en.wikipedia.org/wiki/Levonordefrin
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