Tìm theo
Leuprolide
Các tên gọi khác (8 ) :
  • (D-Leu(6),des-gly-NH2(10),pro-ethylamide(9))-gonadotropin-releasing hormone
  • L-Pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-L-proline ethylamide
  • Leuprorelin
  • Leuprorelina
  • Leuproreline
  • Leuprorelinum
  • PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-NHC2H5
  • PGlu-his-trp-ser-tyr-D-leu-leu-arg-pro-nhet
Thuốc điều trị ung thư
Thuốc Gốc
Biotech
CAS: 53714-56-0
ATC: L02AE02
ĐG : Abbott Laboratories Ltd. , http://www.abbott.com
CTHH: C59H84N16O12
PTK: 1209.3983
Leuprolide belongs to the general class of drugs known as hormones or hormone antagonists. It is a synthetic 9 residue peptide analog of gonadotropin releasing hormone. Leuprolide is used to treat advanced prostate cancer. It is also used to treat uterine fibroids and endometriosis. Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer's disease.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C59H84N16O12
Phân tử khối
1209.3983
Độ kỵ nước
0.1
Dược Lực Học : Used in the palliative treatment of advanced prostate cancer. Leuprolide is a luteinizing hormone agonist that results in suppression of testicular or follicular steroidogenesis.
Cơ Chế Tác Dụng : Leuprolide belongs to the general class of drugs known as hormones or hormone antagonists. It is a synthetic 9 residue peptide analog of gonadotropin releasing hormone. Leuprolide is used to treat advanced prostate cancer. It is also used to treat uterine fibroids and endometriosis. Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer's disease. Leuprolide binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.
Dược Động Học :
▧ Absorption :
Bioavailability by subcutaneous administration is comparable to that by intravenous administration.
▧ Volume of Distribution :
* 27 L [intravenous bolus administration to healthy male volunteers]
▧ Protein binding :
43% to 49%
▧ Metabolism :
Primarily degraded by peptidase and not by cytochrome P450 enzymes.
▧ Route of Elimination :
Excretion in urine
▧ Half Life :
~3 hours
▧ Clearance :
* 8.34 L/h [healthy male receiving a 1-mg IV bolus]
Độc Tính : In rats subcutaneous administration of 250 to 500 times the recommended human dose, expressed on a per body weight basis, resulted in dyspnea, decreased activity, and local irritation at the injection site. There is no evidence at present that there is a clinical counterpart of this phenomenon. In early clinical trials with leuprolide acetate doses as high as 20 mg/day for up to two years caused no adverse effects differing from those observed with the 1 mg/day dose.
Chỉ Định : For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
Liều Lượng & Cách Dùng : Liquid - Subcutaneous
Suspension, extended release - Intramuscular
Suspension, extended release - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Sản phẩm biệt dược : Eligard
  • Công ty :
    Sản phẩm biệt dược : Enantone
  • Công ty : Takeda
    Sản phẩm biệt dược : Leuplin
  • Công ty : Baxter/Teva
    Sản phẩm biệt dược : LeuProMaxx
  • Công ty :
    Sản phẩm biệt dược : Leupromer
  • Sản phẩm biệt dược : Lupron
  • Công ty :
    Sản phẩm biệt dược : Lutrate
  • Công ty : Curaxis
    Sản phẩm biệt dược : Memryte
  • Công ty : Takeda UK
    Sản phẩm biệt dược : Prostap 3
  • Công ty : Takeda UK
    Sản phẩm biệt dược : Prostap SR
  • Công ty : Bayer AG
    Sản phẩm biệt dược : Viadur
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00007
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07612
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D08113
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0024-0793-75
PharmGKB
http://www.pharmgkb.org/drug/PA450203
Wikipedia
http://en.wikipedia.org/wiki/Leuprolide
RxList
http://www.rxlist.com/cgi/generic/eligard.htm
Drugs.com
http://www.drugs.com/cdi/leuprolide.html
... loading
... loading