Tìm theo
Lercanidipine
Các tên gọi khác (2) :
  • Lercanidipine
  • Lercanil
Thuốc tim mạch
Thuốc Gốc
Small Molecule
CAS: 100427-26-7
ATC: C08CA13
CTHH: C36H41N3O6
PTK: 611.7272
Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C36H41N3O6
Phân tử khối
611.7272
Monoisotopic mass
611.299536059
InChI
InChI=1S/C36H41N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30,33,37H,20-21,23H2,1-6H3
InChI Key
InChIKey=ZDXUKAKRHYTAKV-UHFFFAOYSA-N
IUPAC Name
3-{1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Traditional IUPAC Name
lercanidipine
SMILES
COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)(C)CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=C1
Độ hòa tan
1.56e-04 g/l
logP
6.4
logS
-6.6
pKa (Strongest Basic)
9.36
PSA
113.69 Å2
Refractivity
177.85 m3·mol-1
Polarizability
65.78 Å3
Rotatable Bond Count
14
H Bond Acceptor Count
6
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Lercanidipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Lercanidipine is similar to other peripheral vasodilators. Lercanidipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Cơ Chế Tác Dụng : Lercanidipine is a calcium channel blocker of the dihydropyridine class. It is sold under various commercial names including Zanidip. By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Lercanidipine inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Chỉ Định : For the treatment of Hypertension, management of angina pectoris and Raynaud's syndrome
Tương Tác Thuốc :
  • Quinupristin This combination presents an increased risk of toxicity
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00528
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=65866
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508865
ChemSpider
http://www.chemspider.com/Chemical-Structure.59276.html
PharmGKB
http://www.pharmgkb.org/drug/PA164769058
Wikipedia
http://en.wikipedia.org/wiki/Lercanidipine
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