Tìm theo
Latanoprost
Các tên gọi khác (6 ) :
  • Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
  • Latanoprost
  • Latanoprostum
  • PhXA 41
  • Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
  • Xalatan
Thuốc Gốc
Small Molecule
CAS: 130209-82-4
ATC: S01EE01
ĐG : Assia Chemical Industries Ltd.
CTHH: C26H40O5
PTK: 432.5928
Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It is also known by the brand name of Xalatan manufactured by Pfizer.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H40O5
Phân tử khối
432.5928
Monoisotopic mass
432.28757439
InChI
InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
InChI Key
InChIKey=GGXICVAJURFBLW-CEYXHVGTSA-N
IUPAC Name
propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Traditional IUPAC Name
xalatan
SMILES
CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1
Độ hòa tan
8 mg/mL
logP
4.4
logS
-4.5
pKa (strongest acidic)
14.47
pKa (Strongest Basic)
-2.7
PSA
86.99 Å2
Refractivity
124.34 m3·mol-1
Polarizability
50.71 Å3
Rotatable Bond Count
14
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Latanoprost is an isopropyl ester prodrug which is inactive but which becomes active after hydrolysis to the acid from. Latanoprost opthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.
Cơ Chế Tác Dụng : Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It is also known by the brand name of Xalatan manufactured by Pfizer. Latanoprost is a prostaglandin F2a analogue. Specifically, Latanoprost is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and man suggest that the main mechanism of action is increased uveoscleral outflow. Elevated IOP represents a major risk factor for glaucomatous field loss. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss.
Dược Động Học :
▧ Absorption :
Latanoprost is well absorbed through the cornea where the isopropyl ester prodrug is hydrolyzed to the acid form. Peak concentration is reached 2 hrs after topical administration.
▧ Metabolism :
Primarily hepatic (none except hydrolysis in the eye). Latanoprost is an isopropyl ester prodrug. It is hydrolyzed by esterases in the cornea to latanoprost acid, which is biologically active. The portion of the latanoprost acid that reaches the systemic circulation is metabolized primarily by the liver to 1,2-dinor and 1,2,3,4-tetranor metabolites by fatty acid beta-oxidation.
▧ Half Life :
17 minutes
▧ Clearance :
* 7 mL/min/kg
Độc Tính : Symptoms of overdose include bloodshot eyes and eye irritation.
Chỉ Định : For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Tương Tác Thuốc :
  • Bimatoprost The concomitant use of bimatoprost and latanoprost may result in increased intraocular pressure. Consider avoiding this combination of therapy. Monitor for paradoxical increases in intraocular pressure during concomitant use.
Liều Lượng & Cách Dùng : Solution - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Dr. Gerhard Mann
    Sản phẩm biệt dược : Arulatan
  • Công ty : Sophia
    Sản phẩm biệt dược : Gaap
  • Công ty : Sophia
    Sản phẩm biệt dược : Gaap Ofteno
  • Công ty : Chile
    Sản phẩm biệt dược : Gaax
  • Công ty : Atlas
    Sản phẩm biệt dược : Glaucogesic
  • Công ty : Kevelt
    Sản phẩm biệt dược : Glaumax
  • Công ty : Arrow
    Sản phẩm biệt dược : Glauprost
  • Công ty : Pfizer
    Sản phẩm biệt dược : Hysite
  • Công ty : SIFI
    Sản phẩm biệt dược : Iopize
  • Công ty : FDC
    Sản phẩm biệt dược : Ioprost
  • Công ty : Cadila
    Sản phẩm biệt dược : Ioptame
  • Công ty : Klonal
    Sản phẩm biệt dược : Klonaprost
  • Công ty : Synpac-Kingdom
    Sản phẩm biệt dược : Lanoprost
  • Công ty : Kuk Je
    Sản phẩm biệt dược : Lanotan
  • Công ty : Oftalmi
    Sản phẩm biệt dược : Laprost
  • Công ty : Sun-Farm
    Sản phẩm biệt dược : Latacris
  • Công ty : Jelfa
    Sản phẩm biệt dược : Latalux
  • Công ty : Winzer
    Sản phẩm biệt dược : Latan-Ophtal
  • Công ty : Alapis Pharma
    Sản phẩm biệt dược : Lataneau
  • Công ty : Pfizer
    Sản phẩm biệt dược : Xalatan
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00654
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00356
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50150899
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0013-8303-01
PharmGKB
http://www.pharmgkb.org/drug/PA164774763
Wikipedia
http://en.wikipedia.org/wiki/Latanoprost
RxList
http://www.rxlist.com/cgi/generic/latanoprost.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/xal1490.shtml
Drugs.com
http://www.drugs.com/cdi/latanoprost-drops.html
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