Tìm theo
Latamoxef
Các tên gọi khác (6 ) :
  • Lamoxactam
  • Latamoxef
  • Latamoxefum
  • LMOX
  • moxalactam
  • Oxa-cephem
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 64952-97-2
ATC: J01DD06
CTHH: C20H20N6O9S
PTK: 520.473
Broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H20N6O9S
Phân tử khối
520.473
Monoisotopic mass
520.101246958
InChI
InChI=1S/C20H20N6O9S/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32)/t12?,18-,20+/m1/s1
InChI Key
InChIKey=JWCSIUVGFCSJCK-CAVRMKNVSA-N
IUPAC Name
(6R,7R)-7-[2-carboxy-2-(4-hydroxyphenyl)acetamido]-7-methoxy-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
latamoxef
SMILES
[H][C@]12OCC(CSC3=NN=NN3C)=C(N1C(=O)[C@]2(NC(=O)C(C(O)=O)C1=CC=C(O)C=C1)OC)C(O)=O
Độ hòa tan
7.51e-01 g/l
logP
-0.58
logS
-2.8
pKa (strongest acidic)
2.92
pKa (Strongest Basic)
-1.7
PSA
206.3 Å2
Refractivity
133.7 m3·mol-1
Polarizability
47.24 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
12
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Latamoxef works by inhibiting bacterial cell wall biosynthesis.
Cơ Chế Tác Dụng : Broad- spectrum beta-lactam antibiotic similar in structure to the cephalosporins except for the substitution of an oxaazabicyclo moiety for the thiaazabicyclo moiety of certain cephalosporins. It has been proposed especially for the meningitides because it passes the blood-brain barrier and for anaerobic infections. [PubChem] Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain (the penicillin-binding protein) by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.
Dược Động Học :
▧ Absorption :
Rapidly absorbed after oral administration.
▧ Volume of Distribution :
8.51 L
▧ Protein binding :
40%
▧ Route of Elimination :
Renal Excretion accounts for 75 %
▧ Half Life :
1.6 hours
Độc Tính : Latamoxef produces potentially life-threatening effects which include Bleeding, Hypothrombinemia, Platelet dysfunctioning. which are responsible for the discontinuation of Latamoxef therapy. The symptomatic adverse reactions produced by Latamoxef are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Skin rashes, Hematuria, Hyperuricemia, Pyuria, Raised serum creatinine.
Chỉ Định : Latamoxef is an oxacephem antibiotic usually grouped with the cephalosporins. It is used to treat bacterial infections. Latamoxef is primarily indicated in conditions like Bone and joint infection, GI infections, Gynecological infections, Meningitis, Respiratory tract infections, Septicaemia, Skin infections, Soft tissue infections, UTI.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04570
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=47499
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505546
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D08109
ChemSpider
http://www.chemspider.com/Chemical-Structure.43215.html
PharmGKB
http://www.pharmgkb.org/drug/PA164743144
Wikipedia
http://en.wikipedia.org/wiki/Latamoxef
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