Tìm theo
Lactulose
Các tên gọi khác (5 ) :
  • 4-O-beta-D-Galactopyranosyl-D-fructofuranose
  • 4-O-beta-D-Galactopyranosyl-D-fructose
  • Lactulosa
  • Lactulose
  • Lactulosum
Thuốc đường tiêu hóa
Thuốc Gốc
Small Molecule
CAS: 4618-18-2
ATC: A06AD11
ĐG : Actavis Group , http://www.actavis.com
CTHH: C12H22O11
PTK: 342.2965
A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H22O11
Phân tử khối
342.2965
Monoisotopic mass
342.116211546
InChI
InChI=1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12-/m1/s1
InChI Key
InChIKey=JCQLYHFGKNRPGE-FCVZTGTOSA-N
IUPAC Name
(2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
Traditional IUPAC Name
lactulose
SMILES
OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
Độ tan chảy
169 °C
Độ hòa tan
7.64E+005 mg/L (at 30 °C)
logP
-4.3
logS
0.36
pKa (strongest acidic)
10.28
pKa (Strongest Basic)
-3
PSA
189.53 Å2
Refractivity
68.77 m3·mol-1
Polarizability
31.49 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
11
H Bond Donor Count
8
Physiological Charge
0
Number of Rings
2
Bioavailability
0
Dược Lực Học : Therapeutically, lactulose has laxative and ammonia-detoxifying actions. In treating constipation lactulose metabolites draw water into the bowel, causing a cathartic effect through osmotic action.
Cơ Chế Tác Dụng : A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887) Lactulose is a synthetic sugar used in the treatment of constipation and liver disease. It consists of the monosaccharides fructose and galactose. In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of via evolved-beta galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. This in turn causes an increase in stool water content and softens the stool. In treating heptic diseases (hepatic encephalopathy) it is thought that lactulose draws out ammonia from the body in the same way that it draws out water into the colon.
Dược Động Học :
▧ Absorption :
Poorly absorbed from the gastrointestinal tract as no human enzyme that is capable of hydrolysis of this disaccharide is present in human gastrointestinal tissue.
▧ Metabolism :
Lactulose is completely metabolized in the colon by enteric bacteria, and no lactulose is excreted in the feces.
▧ Route of Elimination :
The primary route of elimination is fecal. Urinary excretion has been determined to be 3% or less and is essentially complete within 24 hours.
▧ Half Life :
1.7-2 hours
Độc Tính : LD50=18.2 g/kg (oral, rat). Side effects include diarrhea and resultant dehydration.
Chỉ Định : For the treatment of constipation and hepatic encephalopathy.
Liều Lượng & Cách Dùng : Liquid - Oral
Solution - Oral
Syrup - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Abbott
    Sản phẩm biệt dược : Bifiteral
  • Công ty :
    Sản phẩm biệt dược : Cephulac
  • Công ty : Alra
    Sản phẩm biệt dược : Cholac
  • Công ty :
    Sản phẩm biệt dược : Chronulac
  • Công ty : Alra
    Sản phẩm biệt dược : Constilac
  • Công ty : Actavis
    Sản phẩm biệt dược : Constulose
  • Công ty : Abbott
    Sản phẩm biệt dược : Duphalac
  • Công ty : Actavis
    Sản phẩm biệt dược : Enulose
  • Công ty : Morton Grove
    Sản phẩm biệt dược : Generlac
  • Công ty :
    Sản phẩm biệt dược : Kristalose
  • Công ty : Roche
    Sản phẩm biệt dược : Laevolac
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00581
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=11333
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506757
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07064
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00352
ChemSpider
http://www.chemspider.com/Chemical-Structure.10856.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0054-8486-16
PharmGKB
http://www.pharmgkb.org/drug/PA164748762
Wikipedia
http://en.wikipedia.org/wiki/Lactulose
RxList
http://www.rxlist.com/cgi/generic2/lactulose.htm
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lac_0300.shtml
Drugs.com
http://www.drugs.com/cdi/lactulose-crystals.html
... loading
... loading