Tìm theo
L-Tyrosine
Các tên gọi khác (15 ) :
  • (-)-alpha-amino-P-Hydroxyhydrocinnamic acid
  • (−)-α-amino-p-hydroxyhydrocinnamic acid
  • (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
  • (S)-(-)-Tyrosine
  • (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid
  • (S)-3-(p-Hydroxyphenyl)alanine
  • (S)-alpha-amino-4-Hydroxybenzenepropanoic acid
  • (S)-Tyrosine
  • (S)-α-amino-4-hydroxybenzenepropanoic acid
  • 4-hydroxy-L-phenylalanine
  • L-Tyrosin
  • L-Tyrosine
  • Tyr
  • TYROSINE
  • Y
Thực phẩm chức năng
Thuốc Gốc
Small Molecule
CAS: 60-18-4
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C9H11NO3
PTK: 181.1885
A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H11NO3
Phân tử khối
181.1885
Monoisotopic mass
181.073893223
InChI
InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChI Key
InChIKey=OUYCCCASQSFEME-QMMMGPOBSA-N
IUPAC Name
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid
Traditional IUPAC Name
L-tyrosine
SMILES
N[C@@H](CC1=CC=C(O)C=C1)C(O)=O
Độ tan chảy
343 dec °C
Độ hòa tan
479 mg/L (at 25 °C)
logP
-2.26
logS
-2.57
pKa (strongest acidic)
2
pKa (Strongest Basic)
9.19
PSA
83.55 Å2
Refractivity
47.1 m3·mol-1
Polarizability
18.01 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
2.2 (at 25 °C)
Dược Lực Học : Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. Tyrosine is critical for the production of the body's proteins, enzymes and muscle tissue. Tyrosine is a precursor to the neurotransmitters norepinephrine and dopamine. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. Tyrosine aids in the production of melanin and plays a critical role in the production of thyroxin (thyroid hormones). Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue.
Cơ Chế Tác Dụng : A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem] Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
Dược Động Học :
▧ Absorption :
L-tyrosine is absorbed from the small intestine by a sodium-dependent active transport process.
▧ Metabolism :
In the liver, L-tyrosine is involved in a number of biochemical reactions, including protein synthesis and oxidative catabolic reactions. L-tyrosine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body.
Độc Tính : L-Tyrosine has very low toxicity. There have been very few reports of toxicity. LD50 (oral, rat) > 5110 mg/kg.
Chỉ Định : Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Tyrosine powder
    Giá bán buôn : USD >1.16
    Đơn vị tính : g
  • Biệt dược thương mại : L-tyrosine powder
    Giá bán buôn : USD >0.94
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Rxosine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00135
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6057
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507885
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01536
ChemSpider
http://www.chemspider.com/Chemical-Structure.5833.html
PharmGKB
http://www.pharmgkb.org/drug/PA451822
Wikipedia
http://en.wikipedia.org/wiki/L-Tyrosine
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lty_0256.shtml
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