Tìm theo
L-Phenylalanine
Các tên gọi khác (9 ) :
  • (S)-2-Amino-3-phenylpropionic acid
  • (S)-alpha-Amino-beta-phenylpropionic acid
  • 3-phenyl-L-alanine
  • beta-Phenyl-L-alanine
  • F
  • L-Phenylalanine
  • Phe
  • PHENYLALANINE
  • β-phenyl-L-alanine
Thuốc điều trị về tâm thần
Thuốc Gốc
Small Molecule
CAS: 63-91-2
ĐG : Magno-Humphries Laboratories , http://www.magno-humphries.com
CTHH: C9H11NO2
PTK: 165.1891
An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H11NO2
Phân tử khối
165.1891
Monoisotopic mass
165.078978601
InChI
InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
InChI Key
InChIKey=COLNVLDHVKWLRT-QMMMGPOBSA-N
IUPAC Name
(2S)-2-amino-3-phenylpropanoic acid
Traditional IUPAC Name
L-phenylalanine
SMILES
N[C@@H](CC1=CC=CC=C1)C(O)=O
Độ tan chảy
283 dec °C
Độ hòa tan
2.69E+004 mg/L (at 25 °C)
logP
-1.38
logS
-1.6
pKa (strongest acidic)
2.47
pKa (Strongest Basic)
9.45
PSA
63.32 Å2
Refractivity
45.12 m3·mol-1
Polarizability
17.03 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
1.24 (at 25 °C)
Dược Lực Học : Used by the brain to produce Norepinephrine, a chemical that transmits signals between nerve cells and the brain; keeps you awake and alert; reduces hunger pains; functions as an antidepressant and helps improve memory.
Cơ Chế Tác Dụng : An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem] The mechanism of L-phenylalanine's putative antidepressant activity may be accounted for by its precursor role in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
The mechanism of L-phenylalanine's possible antivitiligo activity is not well understood. It is thought that L-phenylalanine may stimulate the production of melanin in the affected skin
Dược Động Học :
▧ Absorption :
Absorbed from the small intestine by a sodium dependent active transport process.
▧ Metabolism :
Hepatic. L-phenylalanine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body, where it undergoes metabolic reactions similar to those that take place in the liver.
Độc Tính : L-phenylalanine will exacerbate symptoms of phenylketonuria if used by phenylketonurics. L-phenylalanine was reported to exacerbate tardive dyskinesia when used by some with schizophrenia.
Chỉ Định : L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs.
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00120
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6140
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505708
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00079
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00021
ChemSpider
http://www.chemspider.com/Chemical-Structure.5910.html
PharmGKB
http://www.pharmgkb.org/drug/PA450931
Wikipedia
http://en.wikipedia.org/wiki/L-Phenylalanine
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lph_0201.shtml
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