Tìm theo
L-Ornithine
Các tên gọi khác (7 ) :
  • (S)-2,5-Diaminopentanoate
  • (S)-2,5-Diaminopentanoic acid
  • (S)-2,5-diaminovaleric acid
  • (S)-alpha,delta-Diaminovaleric acid
  • (S)-ornithine
  • (S)-α,δ-diaminovaleric acid
  • L-Ornithine
dietary supplements, micronutrients, supplements, non essential amino acids
Thuốc Gốc
Small Molecule
CAS: 70-26-8
ATC: A05BA06, D11AX16, P01CX03
CTHH: C5H12N2O2
PTK: 132.161
Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is a precursor of citrulline and arginine.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H12N2O2
Phân tử khối
132.161
Monoisotopic mass
132.089877638
InChI
InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1
InChI Key
InChIKey=AHLPHDHHMVZTML-BYPYZUCNSA-N
IUPAC Name
(2S)-2,5-diaminopentanoic acid
Traditional IUPAC Name
ornithine
SMILES
NCCC[C@H](N)C(O)=O
Độ tan chảy
140 °C
Độ hòa tan
Appreciable
logP
-4.22
logS
0.11
pKa (strongest acidic)
2.67
pKa (Strongest Basic)
10.29
PSA
89.34 Å2
Refractivity
33.21 m3·mol-1
Polarizability
13.85 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
1.94 (at 25 °C)
Dược Lực Học : A non-essential and nonprotein amino acid, ornithine is critical for the production of the body's proteins, enzymes and muscle tissue. Ornithine plays a central role in the urea cycle and is important for the disposal of excess nitrogen (ammonia). Ornithine is the starting point for the synthesis of many polyamines such as putrescine and spermine. Ornithine supplements are claimed to enhance the release of growth hormone and to burn excess body fat. Ornithine is necessary for proper immune function and good liver function.
Cơ Chế Tác Dụng : Ornithine is an amino acid produced in the urea cycle by the splitting off of urea from arginine. It is a central part of the urea cycle, which allows for the disposal of excess nitrogen. L-Ornithine is a precursor of citrulline and arginine. L-Ornithine is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine).
Dược Động Học :
▧ Absorption :
Absorbed from the small intestine via a sodium-dependent active transport process
▧ Metabolism :
Ornithine undergoes extensive metabolism in the liver to L-arginine, polyamines, and proline, and several other metabolites.
Độc Tính : Oral, rat LD50 = 10000 mg/kg
Chỉ Định : Used for nutritional supplementation, also for treating dietary shortage or imbalance. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.
Liều Lượng & Cách Dùng : Capsule - Oral - 1000 mg
Capsule - Oral - 500 mg
Capsule - Oral - 650 mg
Capsule - Oral - 750 mg
Powder - Oral
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00129
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01602
PharmGKB
http://www.pharmgkb.org/drug/PA164783814
Wikipedia
http://en.wikipedia.org/wiki/Ornithine
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lor_0190.shtml
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