Tìm theo
L-Methionine
Các tên gọi khác (13 ) :
  • (2S)-2-amino-4-(Methylsulfanyl)butanoic acid
  • (S)-2-amino-4-(methylthio)butanoic acid
  • (S)-2-amino-4-(methylthio)butyric acid
  • (S)-methionine
  • L-(-)-Methionine
  • L-a-Amino-g-methylthiobutyric acid
  • L-alpha-amino-gamma-Methylmercaptobutyric acid
  • L-Methionin
  • L-Methionine
  • L-α-amino-γ-methylmercaptobutyric acid
  • M
  • Met
  • Methionine
Thực phẩm chức năng
Thuốc Gốc
Small Molecule
CAS: 63-68-3
ATC: V03AB26
ĐG : Amend
CTHH: C5H11NO2S
PTK: 149.211
A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H11NO2S
Phân tử khối
149.211
Monoisotopic mass
149.051049291
InChI
InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChI Key
InChIKey=FFEARJCKVFRZRR-BYPYZUCNSA-N
IUPAC Name
(2S)-2-amino-4-(methylsulfanyl)butanoic acid
Traditional IUPAC Name
L-methionine
SMILES
CSCC[C@H](N)C(O)=O
Độ tan chảy
283 dec °C
Độ hòa tan
5.66E+004 mg/L (at 25 °C)
logP
-1.87
logS
-0.42
pKa (strongest acidic)
2.53
pKa (Strongest Basic)
9.5
PSA
63.32 Å2
Refractivity
37.59 m3·mol-1
Polarizability
15.5 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
2.28 (at 25 °C)
Dược Lực Học : L-Methionine is a principle supplier of sulfur which prevents disorders of the hair, skin and nails; helps lower cholesterol levels by increasing the liver's production of lecithin; reduces liver fat and protects the kidneys; a natural chelating agent for heavy metals; regulates the formation of ammonia and creates ammonia-free urine which reduces bladder irritation; influences hair follicles and promotes hair growth. L-methionine may protect against the toxic effects of hepatotoxins, such as acetaminophen. Methionine may have antioxidant activity.
Cơ Chế Tác Dụng : A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals. [PubChem] The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cysteine is also a precursor to the antioxidant glutathione. Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free-radical scavenging activity by virtue of its sulfur, as well as its chelating ability.
Dược Động Học :
▧ Absorption :
Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.
▧ Metabolism :
Hepatic
Độc Tính : Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.
Chỉ Định : Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
Liều Lượng & Cách Dùng : Capsule - Oral - 500 mg
Powder - Oral
Tablet - Oral - 200 mg
Tablet - Oral - 500 mg
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Methionine powder
    Giá bán buôn : USD >0.03
    Đơn vị tính : g
  • Biệt dược thương mại : Dl-methionine powder
    Giá bán buôn : USD >0.26
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Acimethin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00134
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6137
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505750
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01733
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D04983
ChemSpider
http://www.chemspider.com/Chemical-Structure.5907.html
PharmGKB
http://www.pharmgkb.org/drug/PA450423
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lme_0173.shtml
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