Tìm theo
L-Lysine
Các tên gọi khác (7 ) :
  • (S)-2,6-diaminohexanoic acid
  • (S)-lysine
  • (S)-α,ε-diaminocaproic acid
  • 6-ammonio-L-norleucine
  • L-lys
  • LYS
  • lysine acid
dietary supplements, micronutrients, amino acids essential, supplements
Thuốc Gốc
Small Molecule
CAS: 56-87-1
ATC: B05XB03
ĐG : Basic Organics , http://www.basicorganics.com
CTHH: C6H14N2O2
PTK: 146.1876
L-Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. L-Lysine is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H14N2O2
Phân tử khối
146.1876
Monoisotopic mass
146.105527702
InChI
InChI=1/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/s2
InChI Key
InChIKey=KDXKERNSBIXSRK-MLHKIVSYNA-N
IUPAC Name
(2S)-2,6-diaminohexanoic acid
Traditional IUPAC Name
L-lysine
SMILES
NCCCC[C@H](N)C(O)=O
Độ tan chảy
224.5 dec °C
Độ hòa tan
1E+006 mg/L (at 20 °C)
logP
-3.05
logS
-0.14
pKa (strongest acidic)
2.74
pKa (Strongest Basic)
10.29
PSA
89.34 Å2
Refractivity
37.81 m3·mol-1
Polarizability
15.84 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
3.12 (at 0 °C)
Dược Lực Học : Insures the adequate absorption of calcium; helps form collagen ( which makes up bone cartilage & connective tissues); aids in the production of antibodies, hormones & enzymes. Recent studies have shown that Lysine may be effective against herpes by improving the balance of nutrients that reduce viral growth. A deficiency may result in tiredness, inability to concentrate, irritability, bloodshot eyes, retarded growth, hair loss, anemia & reproductive problems.
Cơ Chế Tác Dụng : L-Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. L-Lysine is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell. Proteins of the herpes simplex virus are rich in L-arginine, and tissue culture studies indicate an enhancing effect on viral replication when the amino acid ratio of L-arginine to L-lysine is high in the tissue culture media. When the ratio of L-lysine to L-arginine is high, viral replication and the cytopathogenicity of herpes simplex virus have been found to be inhibited. L-lysine may facilitate the absorption of calcium from the small intestine.
Dược Động Học :
▧ Absorption :
Absorbed from the lumen of the small intestine into the enterocytes by an active transport process
▧ Metabolism :
Hepatic
Chỉ Định : Supplemental L-lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00123
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00047
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02304
PharmGKB
http://www.pharmgkb.org/drug/PA450280
Wikipedia
http://en.wikipedia.org/wiki/L-Lysine
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lly_0166.shtml
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