Tìm theo
L-Glutamic Acid
Các tên gọi khác (7 ) :
  • (2S)-2-Aminopentanedioic acid
  • (S)-2-Aminopentanedioic acid
  • (S)-Glutamic acid
  • Glu
  • Glutamic acid
  • L-Glutamate
  • L-Glutaminic acid
Thuốc Gốc
Small Molecule
CAS: 56-86-0
ATC: A09AB01
ĐG : Amend
CTHH: C5H9NO4
PTK: 147.1293
A peptide that is a homopolymer of glutamic acid. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H9NO4
Phân tử khối
147.1293
Monoisotopic mass
147.053157781
InChI
InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChI Key
InChIKey=WHUUTDBJXJRKMK-VKHMYHEASA-N
IUPAC Name
(2S)-2-aminopentanedioic acid
Traditional IUPAC Name
L-glutamic acid
SMILES
N[C@@H](CCC(O)=O)C(O)=O
Độ tan chảy
224 dec °C
Độ hòa tan
8570 mg/L (at 25 °C)
logP
-3.69
logS
-0.26
pKa (strongest acidic)
1.88
pKa (Strongest Basic)
9.54
PSA
100.62 Å2
Refractivity
31.29 m3·mol-1
Polarizability
13.32 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
2.23 (at 0 °C)
Dược Lực Học : In addition to being one of the building blocks in protein synthesis, it is the most widespread neurotransmitter in brain function, as an excitatory neurotransmitter and as a precursor for the synthesis of GABA in GABAergic neurons.
Cơ Chế Tác Dụng : A peptide that is a homopolymer of glutamic acid. [PubChem] Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid cannot cross the blood-brain barrier in appreciable quantities; instead it is converted into L-glutamine, which the brain uses for fuel and protein synthesis. It is conjectured that glutamate is involved in cognitive functions like learning and memory in the brain, though excessive amounts may cause neuronal damage associated in diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. Also, the drug phencyclidine (more commonly known as PCP) antagonizes glutamate at the NMDA receptor, causing behavior reminiscent of schizophrenia. Glutamate in action is extremely difficult to study due to its transient nature.
Dược Động Học :
▧ Absorption :
Absorbed from the lumen of the small intestine into the enterocytes.Absorption is efficient and occurs by an active transport mechanism.
▧ Metabolism :
Hepatic
Độc Tính : Glutamate causes neuronal damage and eventual cell death, particularly when NMDA receptors are activated, High dosages of glutamic acid may include symptoms such as headaches and neurological problems.
Chỉ Định : Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00142
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=33032
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505816
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00025
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00007
ChemSpider
http://www.chemspider.com/Chemical-Structure.30572.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17657
PharmGKB
http://www.pharmgkb.org/drug/PA449776
Wikipedia
http://en.wikipedia.org/wiki/L-Glutamic_Acid
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