Tìm theo
L-Aspartic Acid
Các tên gọi khác (11 ) :
  • (S)-2-aminobutanedioic acid
  • (S)-2-aminosuccinic acid
  • 2-Aminosuccinic acid
  • Asp
  • Aspartic acid
  • D
  • L-Asp
  • L-Asparaginsaeure
  • L-Asparaginsäure
  • L-Aspartate
  • L-Aspartic acid
Thuốc Gốc
Small Molecule
CAS: 56-84-8
ATC: B03AA09
ĐG : Spectrum Pharmaceuticals , http://www.spectrumpharm.com
CTHH: C4H7NO4
PTK: 133.1027
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Phân tử khối
133.1027
Monoisotopic mass
133.037507717
InChI
InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChI Key
InChIKey=CKLJMWTZIZZHCS-REOHCLBHSA-N
IUPAC Name
(2S)-2-aminobutanedioic acid
Traditional IUPAC Name
L-aspartic acid
SMILES
N[C@@H](CC(O)=O)C(O)=O
Độ tan chảy
270 °C
Độ hòa tan
5390 mg/L (at 25 °C)
logP
-3.89
logS
0.03
pKa (strongest acidic)
1.7
pKa (Strongest Basic)
9.61
PSA
100.62 Å2
Refractivity
26.53 m3·mol-1
Polarizability
11.28 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
0
Bioavailability
1
Rule of Five
true
pKa
2.01 (at 0 °C)
Dược Lực Học : L-aspartate is considered a non-essential amino acid, meaning that, under normal physiological conditions, sufficient amounts of the amino acid are synthesized in the body to meet the body's requirements. L-aspartate is formed by the transamination of the Krebs cycle intermediate oxaloacetate. The amino acid serves as a precursor for synthesis of proteins, oligopeptides, purines, pyrimidines, nucleic acids and L-arginine. L-aspartate is a glycogenic amino acid, and it can also promote energy production via its metabolism in the Krebs cycle. These latter activities were the rationale for the claim that supplemental aspartate has an anti-fatigue effect on skeletal muscle, a claim that was never confirmed.
Cơ Chế Tác Dụng : One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. [PubChem] There are also claims that L-aspartate has ergogenic effects, that it enhances performance in both prolonged exercise and short intensive exercise. It is hypothesized that L-aspartate, especially the potassium magnesium aspartate salt, spares stores of muscle glycogen and/or promotes a faster rate of glycogen resynthesis during exercise. It has also been hypothesized that L-aspartate can enhance short intensive exercise by serving as a substrate for energy production in the Krebs cycle and for stimulating the purine nucleotide cycle.
Dược Động Học :
▧ Absorption :
Absorbed from the small intestine by an active transport process
Độc Tính : Mild gastrointestinal side effects including diarrhea. LD50 (rat) > 5,000 mg/kg.
Chỉ Định : There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
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