Tìm theo
Ketamine
Các tên gọi khác (11 ) :
  • (+-)-Ketamine
  • (±)-ketamine
  • 2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone
  • 2-(methylamino)-2-(2-chlorophenyl)cyclohexanone
  • 2-(o-chlorophenyl)-2-(methylamino)-cyclohexanone
  • DL-ketamine
  • Ketamina
  • KETAMINE
  • Ketaminum
  • NMDA
  • Special k
Thuốc gây tê, mê
Thuốc Gốc
Small Molecule
CAS: 6740-88-1
ATC: N01AX03, N01AX14
ĐG : Bedford Labs , http://www.bedfordlabs.com
CTHH: C13H16ClNO
PTK: 237.725
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H16ClNO
Phân tử khối
237.725
Monoisotopic mass
237.092041846
InChI
InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3
InChI Key
InChIKey=YQEZLKZALYSWHR-UHFFFAOYSA-N
IUPAC Name
2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one
Traditional IUPAC Name
ketamine
SMILES
CNC1(CCCCC1=O)C1=CC=CC=C1Cl
Độ tan chảy
92-93
Độ hòa tan
4.64e-02 g/l
logP
2.9
logS
-3.7
pKa (strongest acidic)
18.78
pKa (Strongest Basic)
7.45
PSA
29.1 Å2
Refractivity
65.55 m3·mol-1
Polarizability
24.97 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketamine has been termed “dissociative anesthesia” in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems).
Cơ Chế Tác Dụng : A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. [PubChem] Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following parenteral administration.
▧ Metabolism :
Hepatic.
▧ Half Life :
2.5-3 hours.
Chỉ Định : For use as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation.
Tương Tác Thuốc :
  • Memantine Increased risk of CNS adverse effects with this association
  • Telithromycin Telithromycin may reduce clearance of Ketamine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ketamine if Telithromycin is initiated, discontinued or dose changed.
  • Thiotepa Thiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Ketamine, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Ketamine if Thiotepa is initiated, discontinued or dose changed.
  • Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Ketamine. Consider alternate therapy or monitor for changes in Ketamine therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
  • Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of ketamine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of ketamine if voriconazole is initiated, discontinued or dose changed.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01221
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3821
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508295
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07525
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D08098
ChemSpider
http://www.chemspider.com/Chemical-Structure.3689.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044140
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/61570-581-10
PharmGKB
http://www.pharmgkb.org/drug/PA450144
Wikipedia
http://en.wikipedia.org/wiki/Ketamine
RxList
http://www.rxlist.com/cgi/generic3/ketamine.htm
Drugs.com
http://www.drugs.com/cdi/ketamine.html
... loading
... loading