Tìm theo
KB001
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Biotech
KB001 is a Humaneered™ PEGylated monoclonal antibody fragment for the treatment of life-threatening Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and mechanically ventilated patients.
Dược Lực Học : KaloBios is developing KB001, a PEGylated engineered human Fab' fragment for the prevention and treatment of Pseudomonas aeruginosa infections. The Fab' fragment is specific for the PcrV antigen, an essential component of the Type III secretion system, a key virulence factor with multiple roles in both infection and pathogenesis. KB001 shows potent activity in mouse models of pulmonary infection, reducing mortality and leading to effective clearance of bacteria from infected lungs. This molecule therefore represents an attractive candidate for clinical evaluation in the prevention or treatment of Pseudomonas infection in Cystic Fibrosis, pneumonia, and other indications.
Cơ Chế Tác Dụng : KB001 is a Humaneered™ PEGylated monoclonal antibody fragment for the treatment of life-threatening Pseudomonas aeruginosa infections, a common problem of cystic fibrosis and mechanically ventilated patients. KB001 targets and neutralizes the PcrV protein of the Type III secretion system of the Pseudomonas bacterium, which directly inhibits its toxic effects. This mechanism of action is different from that of other antibiotics and represents a new approach in the treatment of bacterial infections.
Chỉ Định : For the treatment of infections caused by multi-drug resistant Pseudomonas aeruginosa.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05222
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