Tìm theo
K101
Thuốc Gốc
Small Molecule
CTHH: C12H8Cl2O3S
PTK: 303.161
K101 is developed by Moberg Derma for the treatment of onychomycosis (nail fungus) as the primary indication.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H8Cl2O3S
Phân tử khối
303.161
Monoisotopic mass
301.957120226
InChI
InChI=1S/C12H8Cl2O3S/c13-9-1-5-11(6-2-9)17-18(15,16)12-7-3-10(14)4-8-12/h1-8H
InChI Key
InChIKey=RZXLPPRPEOUENN-UHFFFAOYSA-N
IUPAC Name
4-chlorophenyl 4-chlorobenzene-1-sulfonate
Traditional IUPAC Name
mitran
SMILES
ClC1=CC=C(OS(=O)(=O)C2=CC=C(Cl)C=C2)C=C1
Độ hòa tan
7.90e-03 g/l
logP
4.4
logS
-4.6
PSA
43.37 Å2
Refractivity
70.55 m3·mol-1
Polarizability
28.27 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Cơ Chế Tác Dụng : K101 is developed by Moberg Derma for the treatment of onychomycosis (nail fungus) as the primary indication. K101 is a topical solution applied once-daily on affected nails during treatment periods of 3-6 months. In pilot studies, K101 has shown promising results and provides important benefits compared to existing treatment alternatives. There is a significant need for more efficacious topical treatments. For more severe cases of the disease where more than 50% of the nail is affected, the only available options are oral anti-fungals which are associated with a certain risk for severe side effects.
Chỉ Định : Investigated for use/treatment in fungal infections.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB05377
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6635
ChemSpider
http://www.chemspider.com/Chemical-Structure.6383.html
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