Tìm theo
ITMN-191
Thuốc Gốc
Small Molecule
ITMN 191 is a novel oral HCV NS3/4A protease inhibitor being developed by InterMune. ITMN 191 to be metabolized by multiple isoforms of the cytochrome P450 (CYP) enzyme system. ITMN 191 did not inhibit isoforms 1A2, 2C19, 2C9, or 2D6, but did reduce activity of isofom 3A4 by about one-third; this has implications for drug interactions.
Cơ Chế Tác Dụng : ITMN 191 is a novel oral HCV NS3/4A protease inhibitor being developed by InterMune. ITMN 191 to be metabolized by multiple isoforms of the cytochrome P450 (CYP) enzyme system. ITMN 191 did not inhibit isoforms 1A2, 2C19, 2C9, or 2D6, but did reduce activity of isofom 3A4 by about one-third; this has implications for drug interactions. ITMN-191 is a NS3/4A protease inhibitor. The HCV NS3/4A protease is an attractive drug target because of its potential involvement in viral replication and suppressive effects on host response to viral infection. Inhibitors of the HCV protease, such as ITMN-191, represent a promising new class of drugs for HCV.
Chỉ Định : Investigated for use/treatment in hepatitis (viral, C).
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06038
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