Tìm theo
Isopropamide
Các tên gọi khác (3) :
  • Isopropamide
  • SID11112197
  • SID144203913
Thuốc Gốc
Small Molecule
CAS: 7492-32-2
ATC: A03AB09
ĐG : Gallipot , http://www.gallipot.com
CTHH: C23H33N2O
PTK: 353.5209
Isopropamide iodide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H33N2O
Phân tử khối
353.5209
Monoisotopic mass
353.259288688
InChI
InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1
InChI Key
InChIKey=JTPUMZTWMWIVPA-UHFFFAOYSA-O
IUPAC Name
(3-carbamoyl-3,3-diphenylpropyl)(methyl)bis(propan-2-yl)azanium
Traditional IUPAC Name
isopropamide
SMILES
CC(C)[N+](C)(CCC(C(N)=O)(C1=CC=CC=C1)C1=CC=CC=C1)C(C)C
Độ tan chảy
182-184
Độ hòa tan
4.24e-05 g/l
logP
0.14
logS
-7
pKa (strongest acidic)
16.31
pKa (Strongest Basic)
-3.3
PSA
43.09 Å2
Refractivity
120.74 m3·mol-1
Polarizability
41.28 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Isopropamide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
Cơ Chế Tác Dụng : Isopropamide iodide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility. Anticholinergics are a class of medications that inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movements of smooth muscles present in the gastrointestinal tract. Inhibition here decreases acidity and motility, aiding in the treatment of gastrointestinal disorders.
Độc Tính : Symptoms of overdose include dryness of mouth, dysphagia, thirst, blurred vision, dilated pupils, photophobia, fever, rapid pulse and respiration, disorientation. Depression and circulatory collapse may result from severe overdosage.
Chỉ Định : For the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis, biliary dyskinesia and chronic cholelithiasis, duodenitis, gastrointestinal spasm; it may also be used to treat genitourinary spasm.
Tương Tác Thuốc :
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01625
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3775
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507726
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07055
ChemSpider
http://www.chemspider.com/Chemical-Structure.3643.html
PharmGKB
http://www.pharmgkb.org/drug/PA164781398
Wikipedia
http://en.wikipedia.org/wiki/Isopropamide_iodide
... loading
... loading