Tìm theo
Isometheptene
Các tên gọi khác (1) :
  • Isometheptene
Thuốc Gốc
Small Molecule
CAS: 503-01-5
ATC: A03AX10
CTHH: C9H19N
PTK: 141.2539
Isometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H19N
Phân tử khối
141.2539
Monoisotopic mass
141.151749613
InChI
InChI=1S/C9H19N/c1-8(2)6-5-7-9(3)10-4/h6,9-10H,5,7H2,1-4H3
InChI Key
InChIKey=XVQUOJBERHHONY-UHFFFAOYSA-N
IUPAC Name
methyl(6-methylhept-5-en-2-yl)amine
Traditional IUPAC Name
isometheptene
SMILES
CNC(C)CCC=C(C)C
Độ hòa tan
3.06e+00 g/l
logP
2.32
logS
-1.7
pKa (Strongest Basic)
10.67
PSA
12.03 Å2
Refractivity
47.59 m3·mol-1
Polarizability
18.81 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Isometheptene Mucate is an indirect-acting sympathomimetic. Due to its vasoconstricting properties, Isometheptene Mucate is used for the treatment of acute migraine attacks, usually in combination with other analgeics. It can also displace catecholamines from vesicles inside the neuron leading to the sympathetic responses it is known for.
Cơ Chế Tác Dụng : Isometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches. Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine (or their molecular analogues as is the case with this drug). These compounds elicites smooth muscle activation leading to vasoconstriction. These compounds interact with cell surface adrenergic receptors. Such stimuli result in a signal transduction cascade that leads to increased intracellular calcium from the sarcoplasmic reticulum through IP3 mediated calcium release, as well as enhanced calcium entry across the sarcolemma through calcium channels. The rise in intracellular calcium complexes with calmodulin, which in turn activates myosin light chain kinase. This enzyme is responsible for phosphorylating the light chain of myosin to stimulate cross bridge cycling. Once elevated, the intracellular calcium concentration is returned to its basal level through a variety of protein pumps and calcium exchangers located on the plasma membrane and sarcoplasmic reticulum. This reduction in calcium removes the stimulus necessary for contraction allowing for a return to baseline. The drug can also cause vesicular displacement of noradrenaline from the neuron into the synapse with a similar effect as tyramine.
Chỉ Định : Isometheptene is a sympathomimetic drug which causes vasoconstriction. It is used for treating migraines and tension headaches.
Tương Tác Thuốc :
  • Desvenlafaxine Desvenlafaxine may increase the tachycardic and vasopressor effects of isometheptene. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB06706
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=22297
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=99443258
PharmGKB
http://www.pharmgkb.org/drug/PA165958379
Wikipedia
http://en.wikipedia.org/wiki/Isometheptene
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