Tìm theo
Isoflurophate
Các tên gọi khác (19 ) :
  • DFP
  • Diisopropoxyphosphoryl Fluoride
  • Diisopropyl fluorophosphate
  • Diisopropyl Fluorophosphonate
  • Diisopropyl Phosphofluoridate
  • Diisopropyl Phosphorofluoridate
  • Diisopropylfluorophosphate
  • Diisopropylfluorophosphoric acid ester
  • Diisopropylphosphofluoridate
  • Diisopropylphosphorofluoridate
  • Fluorodiisopropyl Phosphate
  • Fluorostigmine
  • Isofluorphate
  • Isoflurophate
  • Isoflurophosphate
  • Isopropyl fluophosphate
  • Isopropyl Phosphorofluoridate
  • Neoglaucit
  • O,O'-diisopropyl phosphoryl fluoride
cholinesterase inhibitors, protease inhibitors, anti glaucoma agents, ophthalmics
Thuốc Gốc
Small Molecule
CAS: 55-91-4
CTHH: C6H14FO3P
PTK: 184.1457
An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H14FO3P
Phân tử khối
184.1457
Monoisotopic mass
184.066459031
InChI
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
InChI Key
InChIKey=MUCZHBLJLSDCSD-UHFFFAOYSA-N
IUPAC Name
bis(propan-2-yl) fluorophosphonate
Traditional IUPAC Name
isoflurophate
SMILES
CC(C)OP(F)(=O)OC(C)C
Độ sôi
62 @ 9mm, 46 @ 5mm
Độ hòa tan
1.54E+004 mg/L (at 25 °C)
logP
1.17
logS
-1.4
pKa (Strongest Basic)
-9.6
PSA
35.53 Å2
Refractivity
40.89 m3·mol-1
Polarizability
16.75 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Isoflurophate is used as ocular drops in the treatment of chronic glaucoma. Isoflurophate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Isoflurophate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Isoflurophate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.
Cơ Chế Tác Dụng : An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330) The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase.
Độc Tính : Signs of overdose include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth.
Chỉ Định : For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Diflupyl
  • Công ty : Merck
    Sản phẩm biệt dược : Floropryl
  • Công ty : Merck
    Sản phẩm biệt dược : Fluopryl
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00677
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5936
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504499
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00202
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00043
ChemSpider
http://www.chemspider.com/Chemical-Structure.5723.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748933
Wikipedia
http://en.wikipedia.org/wiki/Isoflurophate
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