Tìm theo
Isoetarine
Các tên gọi khác (4 ) :
  • Isoetarina
  • Isoetarine
  • Isoetarinum
  • Isoetharine
adrenergic beta 2 receptor agonists, bronchodilator agents
Thuốc Gốc
Small Molecule
CAS: 530-08-5
ATC: R03AC07, R03CC06
ĐG : Nephron Pharmaceuticals Corp. , http://www.nephronpharm.com
CTHH: C13H21NO3
PTK: 239.3107
Isoetarine is a selective adrenergic beta-2 agonist used as fast acting bronchodilator for emphysema, bronchitis and asthma. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H21NO3
Phân tử khối
239.3107
Monoisotopic mass
239.152143543
InChI
InChI=1S/C13H21NO3/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9/h5-8,10,13-17H,4H2,1-3H3
InChI Key
InChIKey=HUYWAWARQUIQLE-UHFFFAOYSA-N
IUPAC Name
4-{1-hydroxy-2-[(propan-2-yl)amino]butyl}benzene-1,2-diol
Traditional IUPAC Name
isoetarine
SMILES
CCC(NC(C)C)C(O)C1=CC(O)=C(O)C=C1
Độ hòa tan
Appreciable
logP
2.2
logS
-1.9
pKa (strongest acidic)
10.01
pKa (Strongest Basic)
9.01
PSA
72.72 Å2
Refractivity
67.34 m3·mol-1
Polarizability
26.39 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
4
H Bond Donor Count
4
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Isoetharine is a relatively selective beta2-adrenergic bronchodilator. Isoetharine is indicated for the relief of bronchospasm associated with chronic obstructive pulmonary disease. Adrenergic bronchodilators are breathed in through the mouth to open up the bronchial tubes (air passages) of the lungs.
Cơ Chế Tác Dụng : Isoetarine is a selective adrenergic beta-2 agonist used as fast acting bronchodilator for emphysema, bronchitis and asthma. [PubChem] The pharmacologic effects of isoetharine are attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Độc Tính : Signs of overdose include tachycardia, palpitations, nausea, headache, and epinephrine-like side effects.
Chỉ Định : For the treatment of asthma, wheezing, and chronic asthmatic bronchitis.
Tương Tác Thuốc :
  • Entacapone Entacapone increases the effect and toxicity of the sympathomimetic, isoetharine.
Liều Lượng & Cách Dùng : Solution - Respiratory (inhalation)
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Bronkometer
  • Công ty :
    Sản phẩm biệt dược : Bronkosol
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00221
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3762
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505384
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07053
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D04625
ChemSpider
http://www.chemspider.com/Chemical-Structure.3630.html
PharmGKB
http://www.pharmgkb.org/drug/PA450103
Wikipedia
http://en.wikipedia.org/wiki/Isoetharine
Drugs.com
http://www.drugs.com/mtm/isoetharine-inhalation.html
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