Tìm theo
Isatoribine
Các tên gọi khác (4 ) :
  • 7-Deaza-7-thia-8-oxoguanosine
  • 7-Thia-8-oxoguanosine
  • 7-TOG
  • ANA245
Thuốc Gốc
Small Molecule
CAS: 122970-40-5
CTHH: C10H12N4O6S
PTK: 316.29
Isatoribine is a selective agonist of TLR7.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H12N4O6S
Phân tử khối
316.29
Monoisotopic mass
316.047754826
InChI
InChI=1S/C10H12N4O6S/c11-9-12-6-5(7(18)13-9)21-10(19)14(6)8-4(17)3(16)2(1-15)20-8/h2-4,8,15-17H,1H2,(H3,11,12,13,18)/t2-,3-,4-,8-/m1/s1
InChI Key
InChIKey=TZYVRXZQAWPIAB-FCLHUMLKSA-N
IUPAC Name
5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2H,3H,4H,7H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione
Traditional IUPAC Name
5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione
SMILES
NC1=NC(=O)C2=C(N1)N([C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)C(=O)S2
Độ hòa tan
3.48e+01 g/l
logP
-2.6
logS
-0.96
pKa (strongest acidic)
7.54
pKa (Strongest Basic)
1.03
PSA
157.71 Å2
Refractivity
78.7 m3·mol-1
Polarizability
28.33 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
9
H Bond Donor Count
5
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Isatoribine is a compound that elevates levels of interferon-alpha and provides antiviral and antimetastatic activity in a variety of murine systems. Isatoribine interacts with a specific receptor, Toll-like receptor 7, or TLR7, that is present on certain immune system cells. The compound also has a promising toxicity profile in multiple species. As of February 2007 this drug was no longer listed on Anadys development pipeline.
Cơ Chế Tác Dụng : Isatoribine is a selective agonist of TLR7. Isatoribine is believed to act by a mechanism of action involving interaction with Toll-like receptor 7 (TLR7) and stimulation of the patient's own immune system, but the precise mechanism by which isatoribine reduced viral load is unknown (possible mechanisms include an antiviral effect, modulation of innate immunity, or enhancement of cellular responses).
Chỉ Định : For the treatment of Hepatitis C.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Immunosine
  • Công ty :
    Sản phẩm biệt dược : Immusine
  • Công ty :
    Sản phẩm biệt dược : Satoribine
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04860
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=72231
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=12014342
ChemSpider
http://www.chemspider.com/Chemical-Structure.65192.html
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