Tìm theo
Iron
Các tên gọi khác (7 ) :
  • 26Fe
  • Eisen
  • Fe
  • fer
  • Ferrum
  • Hierro
  • Iron
trace elements, anti anemic agents, supplements
Thuốc Gốc
Small Molecule
CAS: 7439-89-6
ATC: B03AC07, N06AX19, B03AC02, B03AC01, B03AB02, B03AD03, B03AA07, B03AC06, B03AA03, B03AA02, B03AB06, V08CB03, B03AB07, B03AE10, B03AD01, B03AC03
ĐG : Accucaps Industries Ltd. , http://www.accucaps.com
CTHH: Fe
PTK: 55.845
A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
Fe
Phân tử khối
55.845
Monoisotopic mass
55.934942133
InChI
InChI=1S/Fe
InChI Key
InChIKey=XEEYBQQBJWHFJM-UHFFFAOYSA-N
IUPAC Name
iron
Traditional IUPAC Name
iron
SMILES
[Fe]
Độ tan chảy
1538 °C
logP
-0.77
Polarizability
1.78 Å3
Polar Surface Area (PSA)
0
Refractivity
0
Rotatable Bond Count
0
H Bond Acceptor Count
0
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.
Cơ Chế Tác Dụng : A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia. Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.
Dược Động Học :
▧ Absorption :
The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.
Độc Tính : Acute iron overdosage can be divided into four stages. In the first stage, which occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension, tachycardia and CNS depression ranging from lethargy to coma. The second phase may occur at 6-24 hours after ingestion and is characterized by a temporary remission. In the third phase, gastrointestinal symptoms recur accompanied by shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure and pulmonary edema. The fourth phase may occur several weeks after ingestion and is characterized by gastrointestinal obstruction and liver damage. In a young child, 75 milligrams per kilogram is considered extremely dangerous. A dose of 30 milligrams per kilogram can lead to symptoms of toxicity. Estimates of a lethal dosage range from 180 milligrams per kilogram and upwards. A peak serum iron concentration of five micrograms or more per ml is associated with moderate to severe poisoning in many.
Chỉ Định : Used in preventing and treating iron-deficiency anemia.
Tương Tác Thuốc :
  • Ciprofloxacin Formation of non-absorbable complexes
  • Clodronate Formation of non-absorbable complexes
  • Deferiprone Deferiprone serum concentrations may be decreased by iron salts except for ferric gluconate, ferumoxytol, iron dextran complex, and iron sucrose.
  • Demeclocycline Formation of non-absorbable complexes
  • Doxycycline Formation of non-absorbable complexes
  • Etidronic acid Formation of non-absorbable complexes
  • Gatifloxacin Formation of non-absorbable complexes
  • Gemifloxacin Formation of non-absorbable complexes
  • Grepafloxacin Formation of non-absorbable complexes
  • Ibandronate Formation of non absorbable complexes
  • Levofloxacin Formation of non-absorbable complexes
  • Levothyroxine Iron decreases absorption of levothyroxine
  • Methyldopa Iron decreases the absorption of dopa derivatives
  • Minocycline Formation of non-absorbable complexes
  • Moxifloxacin Formation of non-absorbable complexes
  • Mycophenolate mofetil Oral iron decreases the absorption of mycophenolate-mofetil
  • Norfloxacin Formation of non-absorbable complexes
  • Ofloxacin Formation of non-absorbable complexes
  • Pancrelipase If pancrelipase and iron salts are used in combination then monitor therapy. Pancrelipase may decrease the absorption of iron salts except for ferumoxytol, iron dextran complex, and iron sucrose.
  • Penciclovir The multivalent agent decreases the effect of penicillamine
  • Tetracycline Formation of non-absorbable complexes
  • Trovafloxacin Iron may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the iron containing agent to minimize the interaction.
Liều Lượng & Cách Dùng : Capsule - Oral
Liquid - Intravenous
Liquid - Oral
Liquid - Sublingual
Solution / drops - Oral
Syrup - Oral
Tablet - Oral
Tablet, coated - Oral
Tablet, extended release - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ed-In-Sol
  • Công ty :
    Sản phẩm biệt dược : Fe-40
  • Công ty : GlaxoSmithkline
    Sản phẩm biệt dược : Feosol
  • Công ty :
    Sản phẩm biệt dược : Feostat
  • Công ty :
    Sản phẩm biệt dược : Fer-In-Sol
  • Công ty :
    Sản phẩm biệt dược : Feraheme
  • Công ty : Upsher-Smith
    Sản phẩm biệt dược : Feratab
  • Công ty :
    Sản phẩm biệt dược : Ferate
  • Công ty :
    Sản phẩm biệt dược : Fergon
  • Công ty :
    Sản phẩm biệt dược : Ferralet
  • Công ty :
    Sản phẩm biệt dược : Ferretts
  • Công ty :
    Sản phẩm biệt dược : Ferro sanol
  • Công ty :
    Sản phẩm biệt dược : Ferro-Caps
  • Công ty :
    Sản phẩm biệt dược : Ferro-Time
  • Công ty :
    Sản phẩm biệt dược : Ferrousal
  • Công ty :
    Sản phẩm biệt dược : Siderol
  • Công ty :
    Sản phẩm biệt dược : Simron
  • Công ty :
    Sản phẩm biệt dược : Slow Fe
  • Công ty :
    Sản phẩm biệt dược : Vitedyn-Slo
  • Công ty :
    Sản phẩm biệt dược : Yieronia
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01592
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=23925
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509190
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00023
ChemSpider
http://www.chemspider.com/Chemical-Structure.22368.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/59338-775
PharmGKB
http://www.pharmgkb.org/drug/PA450087
Wikipedia
http://en.wikipedia.org/wiki/Iron
RxList
http://www.rxlist.com/cgi/generic/fedex.htm
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/iro_0149.shtml
Drugs.com
http://www.drugs.com/mtm/ferrous-gluconate.html
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