Tìm theo
Iron Dextran
Các tên gọi khác (2) :
  • Dexferrum
  • Dextran iron
hematinics, anti anemic agents, supplements
Thuốc Gốc
Small Molecule
CAS: 9004-66-4
ĐG : Alaven Pharmaceutical , http://www.alavenpharm.com
Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Độ hòa tan
Soluble
Dược Lực Học : Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Iron is essential to the formation of hemoglobin and to the function and formation of other heme and nonheme compounds. Untreated depletion of iron stores leads to iron-deficient erythropoiesis and, in turn, to iron deficiency anemia.
Cơ Chế Tác Dụng : Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible. After iron dextran is injected, the circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of iron, or to a lesser extent to transferrin. This iron which is subject to physiological control replenishes hemoglobin and depleted iron stores.
Dược Động Học :
▧ Absorption :
The major portion of intramuscular injections of iron dextran is absorbed within 72 hours; most of the remaining iron is absorbed over the ensuing 3 to 4 weeks.
▧ Protein binding :
100% (after release from dextran)
▧ Metabolism :
Dextran, a polyglucose, is either metabolized or excreted.
▧ Route of Elimination :
Dextran, a polyglucose, is either metabolized or excreted.
▧ Half Life :
5 hours (some indications that it can be as long as 10 hours)
Độc Tính : LD50 = 500 mg/kg (mouse, IV). Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Cases of severe, sometimes fatal, allergic reactions (loss of consciousness, collapse, difficulty breathing, hives, swelling, or convulsions) and severe low blood pressure (hypotension) have been reported with the use of iron dextran.
Chỉ Định : For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Injection, solution - Intramuscular
Injection, solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00893
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02141
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/52544-931-02
PharmGKB
http://www.pharmgkb.org/drug/PA164764618
RxList
http://www.rxlist.com/cgi/generic3/fedex.htm
Drugs.com
http://www.drugs.com/cdi/iron-dextran.html
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