Tìm theo
Iophendylate
Thuốc Gốc
Small Molecule
CAS: 99-79-6
CTHH: C19H29IO2
PTK: 416.3368
Iophendylate is a mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization. Iophendylate is a myelographic oil-ester (U.S. Patent 2,348,231). Iophendylate, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors. It next appeared on the world scene for high volume (12-15cc), routine use, in diagnosing disc herniations. A number of clinicians have published on the dangers of oil myelography. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected".
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C19H29IO2
Phân tử khối
416.3368
Monoisotopic mass
416.121223592
InChI
InChI=1S/C19H29IO2/c1-3-22-19(21)15-9-7-5-4-6-8-12-16(2)17-13-10-11-14-18(17)20/h10-11,13-14,16H,3-9,12,15H2,1-2H3
InChI Key
InChIKey=IWRUDYQZPTVTPA-UHFFFAOYSA-N
IUPAC Name
ethyl 10-(2-iodophenyl)undecanoate
Traditional IUPAC Name
iofendylate
SMILES
CCOC(=O)CCCCCCCCC(C)C1=CC=CC=C1I
Độ sôi
196-198
Độ hòa tan
2.52e-05 g/l
logP
7.7
logS
-7.2
pKa (Strongest Basic)
-7
PSA
26.3 Å2
Refractivity
101.6 m3·mol-1
Polarizability
41.29 Å3
Rotatable Bond Count
12
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
1
Bioavailability
0
Dược Lực Học : Iophendylate is a myelographic oil-ester initially introduced for use in small amounts (1-2cc) for locating spinal tumors. Later, it was found to cause adhesive arachnoiditis. Because these substances are hyperbaric once they were placed in the subarachnoid space they would migrate to the distal portion, where they remained, producing progressive scarring.
Cơ Chế Tác Dụng : Iophendylate is a mixture of isomers used as contrast medium, mainly for brain and spinal cord visualization. Iophendylate is a myelographic oil-ester (U.S. Patent 2,348,231). Iophendylate, which was never shown to be safe, was initially introduced for use in small amounts (1-2cc) for locating spinal tumors. It next appeared on the world scene for high volume (12-15cc), routine use, in diagnosing disc herniations. A number of clinicians have published on the dangers of oil myelography. In 1942 Van Wagenen (a neurosurgical colleague of Warrens, at the University of Rochester) identified Iophendylate as causing chemical meningitis in 30 patients where "space-displacing masses within the spinal canal were suspected". Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec.
Chỉ Định : Iophendylate is used as a contrast agent to locate spinal tumors.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ethiodan
  • Công ty :
    Sản phẩm biệt dược : Pantopaque
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01187
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3037234
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508391
ChemSpider
http://www.chemspider.com/Chemical-Structure.2301035.html
PharmGKB
http://www.pharmgkb.org/drug/PA164743143
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