Tìm theo
Ioflupane I 123
Các tên gọi khác (11 ) :
  • 123I-FP-CIT
  • 123I-Ioflupane
  • Datscan
  • Ioflupane
  • ioflupane ((123)I)
  • ioflupane (123I)
  • ioflupane I(123)
  • ioflupano (123I)
  • ioflupanum (123I)
  • methyl (1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-((123)I)iodophenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate
  • Methyl 8-(3-fluoropropyl)-3β-(p-iodo-I(sup 123)-phenyl)-1αH, 5αH-nortropane-2β-carboxylate.
diagnostic agents
Thuốc Gốc
Small Molecule
CAS: 155798-07-5
ATC: V09AB03
CTHH: C18H23FINO2
PTK: 431.2836
Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H23FINO2
Phân tử khối
431.2836
Monoisotopic mass
431.07575061
InChI
InChI=1S/C18H23FINO2/c1-23-18(22)17-15(12-3-5-13(20)6-4-12)11-14-7-8-16(17)21(14)10-2-9-19/h3-6,14-17H,2,7-11H2,1H3/t14?,15-,16?,17+/m1/s1
InChI Key
InChIKey=HXWLAJVUJSVENX-MYBQVCMBSA-N
IUPAC Name
methyl (2S,3S)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
Traditional IUPAC Name
methyl (2S,3S)-8-(3-fluoropropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
SMILES
COC(=O)[C@@H]1C2CCC(C[C@@H]1C1=CC=C(I)C=C1)N2CCCF
Độ tan chảy
82-83
Độ hòa tan
Soluble in water
logP
3.7
logS
-4.9
pKa (Strongest Basic)
9.46
PSA
29.54 Å2
Refractivity
97.34 m3·mol-1
Polarizability
38.79 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : iodine-123 labeled ioflupanebinds selectively to striatal presynaptic dopamine neurons by binding reversibly to presynaptic dopamine transporters.
Cơ Chế Tác Dụng : Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. Iodine-123 labeled ioflupane binds to presynaptic dopamine transporters. When Iodine-123 decays, a gammay ray is emmitted and detected through SPECT.
Dược Động Học :
▧ Absorption :
Absorption is 100% because administered I.V.
▧ Volume of Distribution :
Compared to the entire brain, about 30% of radioactivity is taken up by the striatum.
▧ Route of Elimination :
About 60% is excreted in the urine and 14% in the feces after 48 hours.
▧ Half Life :
Half life is 13.2 hours.
Chỉ Định : Ioflupane I-123 is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor.
Liều Lượng & Cách Dùng : Injection - Intravenous - 5MCI/2.5ML (2MCI/ML)
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08824
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D10014
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/17156-210-01
Wikipedia
http://en.wikipedia.org/wiki/Ioflupane
PDRhealth
http://www.pdrhealth.com/info/v1us/ioflupane
Drugs.com
http://www.drugs.com/mtm/ioflupane-i-123.html
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