Tìm theo
Iodixanol
Các tên gọi khác (3) :
  • 5,5'-((2-Hydroxytrimethylene)bis(acetylimino))bis(N,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide)
  • Indixanol
  • Iodixanolum
contrast media
Thuốc Gốc
Small Molecule
CAS: 92339-11-2
ATC: V08AB09
ĐG : GE Healthcare Inc. , http://www.gehealthcare.com
CTHH: C35H44I6N6O15
PTK: 1550.1819
Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C35H44I6N6O15
Phân tử khối
1550.1819
Monoisotopic mass
1549.713275288
InChI
InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62)
InChI Key
InChIKey=NBQNWMBBSKPBAY-UHFFFAOYSA-N
IUPAC Name
5-{N-[3-(N-{3,5-bis[(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodophenyl}acetamido)-2-hydroxypropyl]acetamido}-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
Traditional IUPAC Name
iodixanol
SMILES
CC(=O)N(CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I
Độ hòa tan
1.85e-01 g/l
logP
0.5
logS
-3.9
pKa (strongest acidic)
11.43
pKa (Strongest Basic)
-3.2
PSA
339.09 Å2
Refractivity
277.16 m3·mol-1
Polarizability
111.45 Å3
Rotatable Bond Count
22
H Bond Acceptor Count
15
H Bond Donor Count
13
Physiological Charge
0
Number of Rings
2
Bioavailability
0
Dược Lực Học : Iodixanol is a contrast agent commonly used during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. It is an iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H20, the same as blood.
Cơ Chế Tác Dụng : Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. Organic iodine compounds attenuate x-rays as they pass through the body, thereby allowing the body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intravascular administration, iodixanol makes opaque those internal structures in its path of flow, allowing their visualization until significant hemodilution and elimination occur.
Dược Động Học :

▧ Volume of Distribution :
* 0.26 L/kg
▧ Protein binding :
Negligible
▧ Metabolism :
Excreted unchanged
▧ Route of Elimination :
In adults, approximately 97% of the injected dose of iodixanol is excreted unchanged in urine within 24 hours, with less than 2% excreted in feces within five days post-injection.
▧ Half Life :
2.1 hours. In patients with significantly impaired renal function (mean creatinine clearance rate, 9.91 [± 3.58] mL per minute), the plasma half-life is increased to 23 hours.
Độc Tính : Non-ionic radiocontrast agents like iodixanol are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Chỉ Định : Iodixanol is a contrast agent during coronary angiography.
Liều Lượng & Cách Dùng : Solution - Intra-arterial
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Visipaque
  • Công ty :
    Sản phẩm biệt dược : Visipaque 270
  • Công ty :
    Sản phẩm biệt dược : Visipaque 320
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01249
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3724
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504687
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01474
ChemSpider
http://www.chemspider.com/Chemical-Structure.3593.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0407-2222-01
PharmGKB
http://www.pharmgkb.org/drug/PA164783998
Wikipedia
http://en.wikipedia.org/wiki/Iodixanol
Drugs.com
http://www.drugs.com/mtm/iodixanol.html
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