Tìm theo
Iodipamide
Các tên gọi khác (4 ) :
  • Adipiodona
  • Adipiodone
  • Adipiodonum
  • Iodipamide
contrast media
Thuốc Gốc
Small Molecule
CAS: 606-17-7
ĐG : Bracco Diagnostics Inc. , http://www.bracco.com
CTHH: C20H14I6N2O6
PTK: 1139.7618
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H14I6N2O6
Phân tử khối
1139.7618
Monoisotopic mass
1139.51199671
InChI
InChI=1S/C20H14I6N2O6/c21-7-5-9(23)17(15(25)13(7)19(31)32)27-11(29)3-1-2-4-12(30)28-18-10(24)6-8(22)14(16(18)26)20(33)34/h5-6H,1-4H2,(H,27,29)(H,28,30)(H,31,32)(H,33,34)
InChI Key
InChIKey=FFINMCNLQNTKLU-UHFFFAOYSA-N
IUPAC Name
3-{5-[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]pentanamido}-2,4,6-triiodobenzoic acid
Traditional IUPAC Name
iodipamide
SMILES
OC(=O)C1=C(I)C(NC(=O)CCCCC(=O)NC2=C(I)C=C(I)C(C(O)=O)=C2I)=C(I)C=C1I
Độ tan chảy
306-308
Độ hòa tan
460 mg/L (at 20 °C)
logP
8.25
logS
-5.6
pKa (strongest acidic)
2.03
pKa (Strongest Basic)
-3.4
PSA
132.8 Å2
Refractivity
183.98 m3·mol-1
Polarizability
69.71 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
6
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
2
Bioavailability
0
Dược Lực Học : Following intravenous administration of Cholografin Meglumine, iodipamide is carried to the liver where it is rapidly secreted. The contrast medium appears in the bile within 10 to 15 minutes after injection, thus permitting visualization of the hepatic and common bile ducts, even in cholecystectomized patients. The biliary ducts are readily visualized within about 25 minutes after administration, except in patients with impaired liver function. The gallbladder begins to fill within an hour after injection; maximum filling is reached after two to two and one-half hours. The contrast medium is finally eliminated in the feces without passing through the enterohepatic circulation, except for approximately 10 percent of the intravenously administered dose which is excreted through the kidneys.
Cơ Chế Tác Dụng : Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. [PubChem] Organic iodine compounds block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these iodinated organic compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. Iodipamide's primary excretion through the hepato-biliary system and concentration in bile allows visualization of the gallbladder and biliary ducts.
Dược Động Học :

▧ Metabolism :
Hepatic.
Độc Tính : Ionic radiocontrast agents like iodipamide are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress. Acute IV LD50 is 5000 mg/kg in rat, 3195 mg/kg in mouse, and 1200 mg/kg in dog.
Chỉ Định : Iodipamide is used as a contrast agent for cholecystography and intravenous cholangiography.
Liều Lượng & Cách Dùng : Injection, solution - Intravenous drip
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Schering
    Sản phẩm biệt dược : Biligrafin
  • Công ty : Bracco
    Sản phẩm biệt dược : Cholografin Meglumine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04711
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3739
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507320
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01774
ChemSpider
http://www.chemspider.com/Chemical-Structure.3608.html
PharmGKB
http://www.pharmgkb.org/drug/PA164745532
... loading
... loading