Tìm theo
Interferon gamma-1b
Các tên gọi khác (3) :
  • IFN-gamma
  • Immune interferon
  • Interferon gamma precursor
Thuốc giảm miễn dịch
Thuốc Gốc
Biotech
CAS: 82115-62-6
ĐG : InterMune Inc. , http://www.intermune.com
CTHH: C761H1206N214O225S6
PTK: 17145.6000
Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C761H1206N214O225S6
Phân tử khối
17145.6000
Độ tan chảy
61 °C
Độ kỵ nước
-0.823
Điểm đẳng điện tích
9.54
Dược Lực Học : IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon gamma-1b may prevent excessive scarring.
Cơ Chế Tác Dụng : Human Interferon gamma-1b (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography. The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b. Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.
Chỉ Định : Interferon gamma-1b is used for the treatment of Chronic granulomatous disease and Osteopetrosis.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : InterMune Inc
    Sản phẩm biệt dược : Actimmune
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00033
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/X13274
PharmGKB
http://www.pharmgkb.org/drug/PA164746386
Wikipedia
http://en.wikipedia.org/wiki/Interferon_gamma-1b
Drugs.com
http://www.drugs.com/cdi/interferon-gamma-1b.html
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