Interferon beta-1b

Các tên gọi khác (3) :

Fibroblast interferon
IFN-beta
Interferon beta precursor

Thuốc giảm miễn dịch

Thuốc Gốc

Biotech

CAS: 145155-23-3

ATC: L03AB08

ĐG : Bayer Healthcare , http://www.bayerhealthcare.com

CTHH: C₉₀₈H₁₄₀₈N₂₄₆O₂₅₃S₆

PTK: 20011.0000

Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD

Nhận Dạng Quốc Tế & Đặc Tính Hóa Học

Công thức hóa học

C₉₀₈H₁₄₀₈N₂₄₆O₂₅₃S₆

Phân tử khối

20011.0000

Độ kỵ nước

-0.447

Điểm đẳng điện tích

9.02

Dược Lực Học : Interferon beta upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Type I interferons also induce the synthesis of several key antiviral mediators including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin, neopterin and protein kinase R.

Cơ Chế Tác Dụng : Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.

Dược Động Học :

▧ Volume of Distribution :
* 0.25 to 2,88 L/kg
▧ Clearance :
* 9.4 – 28.9 mL/min•kg-1 [patients with diseases other than MS receiving single intravenous doses up to 2.0 mg]

Chỉ Định : Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks.

Tương Tác Thuốc :

Zidovudine The interferon increases the effect and toxicity of zidovudine

Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Subcutaneous

Dữ Kiện Thương Mại

Giá thị trường

Biệt dược thương mại : Extavia 0.3 mg kit

Giá bán buôn : USD >196.76

Đơn vị tính : kit
Biệt dược thương mại : Betaseron 0.3 mg kit

Giá bán buôn : USD >227.69

Đơn vị tính : kit
Biệt dược thương mại : Betaseron 14 0.3 mg Solution 1 Box Contains Fourteen .3 mg Vials.

Giá bán buôn : USD >3315.06

Đơn vị tính : box

Nhà Sản Xuất

Công ty : Chiron Corp

Sản phẩm biệt dược : Betaseron

Đóng gói

Công ty : Bayer Healthcare

Website : http://www.bayerhealthcare.com
Công ty : Berlex Labs

Website : http://www.berlex.com
Công ty : Chiron Corp.

Website : http://www.chiron.com
Công ty : InterMune Inc.

Website : http://www.intermune.com
Công ty : Novartis AG

Website : http://www.novartis.com

Tài Liệu Tham Khảo Thêm

drugbank

http://www.drugbank.ca/drugs/DB00068

KEGG Compound

http://www.genome.jp/dbget-bin/www_bget?cpd:C07901

KEGG Drug

http://www.genome.jp/dbget-bin/www_bget?drug:D00746

National Drug Code Directory

http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/50419-523-35

GenBank

http://www.ncbi.nlm.nih.gov/nuccore/V00534

PharmGKB

http://www.pharmgkb.org/drug/PA450039

Wikipedia

http://en.wikipedia.org/wiki/Interferon_beta-1b

RxList

http://www.rxlist.com/cgi/generic/interferon_beta.htm

Drugs.com

http://www.drugs.com/cdi/interferon-beta-1b-solution.html

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