Tìm theo
Interferon beta-1b
Các tên gọi khác (3) :
  • Fibroblast interferon
  • IFN-beta
  • Interferon beta precursor
Thuốc giảm miễn dịch
Thuốc Gốc
Biotech
CAS: 145155-23-3
ATC: L03AB08
ĐG : Bayer Healthcare , http://www.bayerhealthcare.com
CTHH: C908H1408N246O253S6
PTK: 20011.0000
Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C908H1408N246O253S6
Phân tử khối
20011.0000
Độ kỵ nước
-0.447
Điểm đẳng điện tích
9.02
Dược Lực Học : Interferon beta upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Type I interferons also induce the synthesis of several key antiviral mediators including 2'-5' oligoadenylate synthetase (2'-5' A synthetase), beta-2 microglobulin, neopterin and protein kinase R.
Cơ Chế Tác Dụng : Human interferon beta (165 residues), cysteine 17 is substituted with serine. Produced in E. coli, no carbohydrates, MW=18.5kD Interferon beta binds to type I interferon receptors (IFNAR1 and IFNAR2c) which activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon beta binds more stably to type I interferon receptors than interferon alpha.
Dược Động Học :

▧ Volume of Distribution :
* 0.25 to 2,88 L/kg
▧ Clearance :
* 9.4 – 28.9 mL/min•kg-1 [patients with diseases other than MS receiving single intravenous doses up to 2.0 mg]
Chỉ Định : Interferon beta-1b is a drug used for the treatment of relapsing/remitting multiple sclerosis. It has been shown to slow the advance of the disease as well as to decrease the frequency of attacks.
Tương Tác Thuốc :
  • Zidovudine The interferon increases the effect and toxicity of zidovudine
Liều Lượng & Cách Dùng : Injection, powder, lyophilized, for solution - Subcutaneous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Chiron Corp
    Sản phẩm biệt dược : Betaseron
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00068
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07901
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00746
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/50419-523-35
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/V00534
PharmGKB
http://www.pharmgkb.org/drug/PA450039
Wikipedia
http://en.wikipedia.org/wiki/Interferon_beta-1b
RxList
http://www.rxlist.com/cgi/generic/interferon_beta.htm
Drugs.com
http://www.drugs.com/cdi/interferon-beta-1b-solution.html
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