Tìm theo
Insulin, porcine
Insulin và nhóm Thuốc hạ đường huyết
Thuốc Gốc
Biotech
CAS: 9004-14-2
CTHH: C257H387N65O76S6
PTK: 5795.6000
Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C257H387N65O76S6
Phân tử khối
5795.6000
Độ hòa tan
Slightly soluble
Độ kỵ nước
0.218
Điểm đẳng điện tích
5.39
Dược Lực Học : Insulin is used in the treatment of type I and type II diabetes. The primary activity of insulin is the regulation of glucose metabolism. In muscle and other tissues (except the brain), insulin causes rapid transport of glucose and amino acids intracellularly. It also promotes anabolism, and inhibits protein catabolism. In the liver, insulin promotes the uptake and storage of glucose in the form of glycogen, inhibits gluconeogenesis, and promotes the conversion of excess glucose into fat.
Cơ Chế Tác Dụng : Insulin isolated from pig pancreas. Composed of alpha and beta chains, processed from pro-insulin. Forms a hexameric structure. Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism.
Dược Động Học :

▧ Metabolism :
Insulin is predominantly cleared by metabolic degradation via a receptor-mediated process.
Chỉ Định : For the treatment of type I and II diabetes mellitus.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Lilly
    Sản phẩm biệt dược : Iletin II
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00071
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/AY137503
PharmGKB
http://www.pharmgkb.org/drug/PA164781053
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