Tìm theo
Indecainide
Các tên gọi khác (3) :
  • Indecainida
  • Indecainide
  • Indecainidum
Thuốc chống loạn nhịp
Thuốc Gốc
Small Molecule
CAS: 74517-78-5
CTHH: C20H24N2O
PTK: 308.4174
Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H24N2O
Phân tử khối
308.4174
Monoisotopic mass
308.1888634
InChI
InChI=1S/C20H24N2O/c1-14(2)22-13-7-12-20(19(21)23)17-10-5-3-8-15(17)16-9-4-6-11-18(16)20/h3-6,8-11,14,22H,7,12-13H2,1-2H3,(H2,21,23)
InChI Key
InChIKey=UCEWGESNIULAGX-UHFFFAOYSA-N
IUPAC Name
9-{3-[(propan-2-yl)amino]propyl}-9H-fluorene-9-carboxamide
Traditional IUPAC Name
indecainide
SMILES
CC(C)NCCCC1(C(N)=O)C2=CC=CC=C2C2=CC=CC=C12
Độ tan chảy
94-95 °C
Độ hòa tan
1.88 mg/L
logP
3.11
logS
-5.5
pKa (strongest acidic)
16.51
pKa (Strongest Basic)
10.4
PSA
55.12 Å2
Refractivity
94.05 m3·mol-1
Polarizability
35.56 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics.
Cơ Chế Tác Dụng : Indecainide is a rarely used antidysrhythmic. Indecainide has local anesthetic activity and belongs to the membrane stabilizing (Class 1) group of antiarrhythmic agents; it has electrophysiologic effects characteristic of the IC class of antiarrhythmics. Indecainide acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.
Dược Động Học :
▧ Absorption :
Nearly complete following oral administration.
Độc Tính : When given orally to either young adult rats or mice, the LD50 was 100 mg/kg. Symptoms of overdose include nausea and vomiting, convulsions, hypotension, bradycardia, syncope, extreme widening of the QRS complex, widening of the QT interval, widening of the PR interval, ventricular tachycardia, AV nodal block, asystole, bundle branch block, cardiac failure, and cardiac arrest.
Chỉ Định : For the treatment of life-threatening dysrhythmias and sustained ventricular tachycardia.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Eli Lilly
    Sản phẩm biệt dược : Decabid
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00192
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=52195
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506714
ChemSpider
http://www.chemspider.com/Chemical-Structure.47194.html
PharmGKB
http://www.pharmgkb.org/drug/PA164754881
Wikipedia
http://en.wikipedia.org/wiki/Indecainide
... loading
... loading