Tìm theo
Implitapide
Các tên gọi khác (1) :
  • AEGR427
Thuốc Gốc
Small Molecule
CAS: 177469-96-4
CTHH: C35H37N3O2
PTK: 531.6872
Implitapide is a microsomal triglyceride transfer protein (MTP)-inhibitor.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C35H37N3O2
Phân tử khối
531.6872
Monoisotopic mass
531.288577443
InChI
InChI=1S/C35H37N3O2/c1-23-19-24(2)36-34-32(23)29-17-8-9-18-31(29)38(34)21-25-11-10-16-28(20-25)33(27-14-6-7-15-27)35(40)37-30(22-39)26-12-4-3-5-13-26/h3-5,8-13,16-20,27,30,33,39H,6-7,14-15,21-22H2,1-2H3,(H,37,40)/t30-,33-/m0/s1
InChI Key
InChIKey=AMNXBQPRODZJQR-DITALETJSA-N
IUPAC Name
(2S)-2-cyclopentyl-2-[3-({2,4-dimethyl-9H-pyrido[2,3-b]indol-9-yl}methyl)phenyl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide
Traditional IUPAC Name
(2S)-2-cyclopentyl-2-[3-({2,4-dimethylpyrido[2,3-b]indol-9-yl}methyl)phenyl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide
SMILES
CC1=NC2=C(C3=CC=CC=C3N2CC2=CC(=CC=C2)[C@H](C2CCCC2)C(=O)N[C@@H](CO)C2=CC=CC=C2)C(C)=C1
Độ hòa tan
2.02e-04 g/l
logP
6.68
logS
-6.4
pKa (strongest acidic)
13.4
pKa (Strongest Basic)
4.35
PSA
67.15 Å2
Refractivity
160.14 m3·mol-1
Polarizability
59.8 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
6
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP), a key enzyme involved in the assembly and release of cholesterol and triglyceride from the liver and intestinal tract. It is being investigated for the treatment of atherosclerosis.
Cơ Chế Tác Dụng : Implitapide is a microsomal triglyceride transfer protein (MTP)-inhibitor. MTP mediates triglyceride absorption and chylomicron secretion from the intestine and very-low-density lipoprotein (VLDL) secretion from the liver by linking lipid molecules with apolipoprotein B (apoB). Inhibition of MTP reduces the level of all apoB-containing lipoproteins, including LDL.
Chỉ Định : For the treatment of atherosclerosis.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04852
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5745206
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3846279
ChemSpider
http://www.chemspider.com/Chemical-Structure.4676524.html
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