Tìm theo
Imiquimod
Các tên gọi khác (6 ) :
  • 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
  • 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
  • Imiquimod
  • Imiquimodum
  • R 837
  • Zartra
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 99011-02-6
ATC: D06BB10
ĐG : 3M Health Care , http://www.3m.com
CTHH: C14H16N4
PTK: 240.3036
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H16N4
Phân tử khối
240.3036
Monoisotopic mass
240.137496532
InChI
InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChI Key
InChIKey=DOUYETYNHWVLEO-UHFFFAOYSA-N
IUPAC Name
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
Traditional IUPAC Name
imiquimod
SMILES
CC(C)CN1C=NC2=C1C1=CC=CC=C1N=C2N
Độ tan chảy
292-294 °C
Độ hòa tan
Poorly soluble
logP
2.7
logS
-3
pKa (Strongest Basic)
5.4
PSA
56.73 Å2
Refractivity
72.54 m3·mol-1
Polarizability
26.67 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. It is not used on warts inside the vagina, penis, or rectum. Imiquimod is also used to treat a skin condition of the face and scalp called actinic keratoses. Imiquimod can also be used to treat certain types of skin cancer called superficial basal cell carcinoma. Imiquimod is particularly useful on areas where surgery or other treatments may be difficult, complicated or otherwise undesirable, especially the face and lower legs.
Cơ Chế Tác Dụng : Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma. Imiquimod's mechanism of action is via stimulation of innate and acquired immune responses, which ultimately leads to inflammatory cell infiltration within the field of drug application followed by apoptosis of diseased tissue. Imiquimod does not have direct antiviral activity. Studies of mice show that imiquimod may induce cytokines, including interferon-alpha (IFNA) as well as several IFNA genes (IFNA1, IFNA2, IFNA5, IFNA6, and IFNA8) as well as the IFNB gene. Imiquimod also induced the expression of interleukin (IL)-6, IL-8, and tumor necrosis factor alpha genes. In the treatment of basal cell carcinoma, Imiquimod appears to act as a toll-like receptor-7 agonist, and is thought to exert its anti-tumor effect via modification of the immune response and stimulation of apoptosis in BCC cells. In treating basal cell carcinoma it may increase the infiltration of lymphocytes, dendritic cells, and macrophages into the tumor lesion.
Dược Động Học :
▧ Absorption :
Well absorbed through skin (as a cream)
▧ Half Life :
20 hours (topical dose), 2 hours (subcutaneous dose)
Độc Tính : Symptoms of overdose include flu-like symptoms, such as fever, fatigue, headache, nausea, diarrhoea and muscle pain.
Chỉ Định : For the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above.
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Zyclara 3.75% cream
    Giá bán buôn : USD >24.43
    Đơn vị tính : each
  • Biệt dược thương mại : Aldara 5% cream
    Giá bán buôn : USD >26.04
    Đơn vị tính : each
  • Biệt dược thương mại : Imiquimod 5% cream
    Giá bán buôn : USD >33.17
    Đơn vị tính : each
  • Biệt dược thương mại : Imiquimod 5% Cream Packet
    Giá bán buôn : USD >42.89
    Đơn vị tính : packet
  • Biệt dược thương mại : Aldara 5% Cream Pack
    Giá bán buôn : USD >46.99
    Đơn vị tính : pack
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00724
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=57469
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505394
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02500
ChemSpider
http://www.chemspider.com/Chemical-Structure.51809.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0168-0432-24
PharmGKB
http://www.pharmgkb.org/drug/PA449972
Wikipedia
http://en.wikipedia.org/wiki/Imiquimod
RxList
http://www.rxlist.com/cgi/generic/imiquimod.htm
Drugs.com
http://www.drugs.com/cdi/imiquimod.html
... loading
... loading