Tìm theo
Idoxuridine
Các tên gọi khác (16 ) :
  • (+)-5-Iodo-2'-deoxyuridine
  • 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil
  • 1-beta-D-2'-Deoxyribofuranosyl-5-iodouracil
  • 1beta-D-2'-Deoxyribofuranosyl-5-iodouracil
  • 2'-Deoxy-5-iodouridine
  • 5-iodo-2'-deoxyuridine
  • 5-Iododeoxyuridine
  • 5-Iodouracil deoxyriboside
  • Idoxuridin
  • Idoxuridina
  • Idoxuridine
  • Idoxuridinum
  • IdU
  • Iododeoxyridine
  • Iodoxuridine
  • Joddeoxiuridin
antiviral agents, nucleic acid synthesis inhibitors
Thuốc Gốc
Small Molecule
CAS: 54-42-2
ATC: D06BB01, J05AB02, S01AD01
ĐG : Medisca Inc. , http://www.medisca.com
CTHH: C9H11IN2O5
PTK: 354.0985
An analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H11IN2O5
Phân tử khối
354.0985
Monoisotopic mass
353.971264892
InChI
InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI Key
InChIKey=XQFRJNBWHJMXHO-RRKCRQDMSA-N
IUPAC Name
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione
Traditional IUPAC Name
idoxuridine
SMILES
OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(I)C(=O)NC1=O
Độ tan chảy
193
Độ hòa tan
2000 mg/L (at 25 °C)
logP
-0.96
logS
-1.2
pKa (strongest acidic)
8.06
pKa (Strongest Basic)
-3
PSA
99.1 Å2
Refractivity
64.4 m3·mol-1
Polarizability
26.06 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : In chemical structure idoxuridine closely approximates the configuration of thymidine, one of the four building blocks of DNA (the genetic material of the Herpes virus). As a result, idoxuridine is able to replace thymidine in the enzymatic step of viral replication or "growth". The consequent production of faulty DNA results in a pseudostructure which cannot infect or destroy tissue. In short, by pre-empting a vital building block in the genetic material of the Herpes simplex virus, Herplex-D topical solution destroys the infective and destructive capacity of the viral material. The virus infected cell may only be attacked during the period of active synthesis of DNA. This occurs early in the development of the Herpes simplex lesion, but at different times in different cells. Therefore, ideally, the affected area should remain saturated with the antiviral agent.
Cơ Chế Tác Dụng : An analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent. [PubChem] Idoxuridine acts as an antiviral agent by inhibiting viral replication by substituting itself for thymidine in viral DNA. This in turn inhibits thymidylate phosphorylase and viral DNA polymerases from properly functioning. The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.
Dược Động Học :
▧ Absorption :
Systemic absorption is unlikely following ocular administration even when nasolacrimal secretions are swallowed, since vidarabine is rapidly deaminated in the gastrointestinal tract.
▧ Metabolism :
Idoxuridine is rapidly inactivated by deaminases or nucleotidases.
Độc Tính : Hypersensitivity or increased sensitivity of eyes to light. LD50=3080 mg/kg (orally in mice).
Chỉ Định : For use in keratoconjunctivitis and keratitis caused by herpes simplex virus.
Liều Lượng & Cách Dùng : Liquid - Topical
Solution / drops - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Idoxuridine powder
    Giá bán buôn : USD >273.88
    Đơn vị tính : g
Nhà Sản Xuất
  • Công ty : Alcon
    Sản phẩm biệt dược : Dendrid
  • Công ty : Astellas
    Sản phẩm biệt dược : Herpid
  • Công ty : Ciba Vision
    Sản phẩm biệt dược : Herpidu
  • Công ty : Allergan
    Sản phẩm biệt dược : Herplex
  • Công ty : Elea
    Sản phẩm biệt dược : Idulea
  • Công ty : Sanofi
    Sản phẩm biệt dược : Idustatin
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Keresid
  • Công ty : Santen
    Sản phẩm biệt dược : Oftan IDU
  • Công ty : Viñas
    Sản phẩm biệt dược : Virexen
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00249
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5905
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507573
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00342
ChemSpider
http://www.chemspider.com/Chemical-Structure.5694.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0065-0029-15
PharmGKB
http://www.pharmgkb.org/drug/PA164781019
Wikipedia
http://en.wikipedia.org/wiki/Idoxuridine
Drugs.com
http://www.drugs.com/mtm/idoxuridine-ophthalmic.html
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