Tìm theo
Icodextrin
Các tên gọi khác (4 ) :
  • Icodextrin
  • Icodextrina
  • Icodextrine
  • Icodextrinum
dialysis solutions, diuretics osmotic
Thuốc Gốc
Small Molecule
CAS: 337376-15-5
ĐG : Baxter International Inc. , http://www.baxter.com
Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Độ hòa tan
80 mg/mL
Dược Lực Học : Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways.
Cơ Chế Tác Dụng : Icodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stage renal disease. It is injected as a solution into the peritoneal cavity. The drug is absorbed via convective transport via peritoneal lymphatic pathways. Icodextrin is a starch-derived, water-soluble glucose polymer linked by alpha (1-4) and alpha (1-6) glycosidic bonds with an average molecular weight between 13,000 and 19,000 daltons. It functions as a colloid osmotic agent to achieve ultrafiltration during long (12-16 hour) peritoneal dialysis dwells. In other words it helps clean waste out of the body when the kidneys are not functioning properly. Icodectrin acts in the peritoneal cavity by exerting osmotic pressure across small intercellular pores resulting in transcapillary ultrafiltration through the dwell. This is due to the fact that the polymer is minimially absorbed across the peritoneal membrane. Icodextrin achieves superior fluid removal compared with glucose-based dialysates.
Dược Động Học :
▧ Absorption :
40% of instilled icodextrin was absorbed from the peritoneal solution during a 12-hour dwell.
▧ Metabolism :
Icodextrin is metabolized by alpha-amylase into oligosaccharides with a lower degree of polymerization), including maltose, maltotriose, maltotetraose, and higher molecular weight species.
Chỉ Định : Used for continuous ambulatory peritoneal dialysis (CAPD) of diabetic patients or automated peritoneal dialysis (APD) for the management of end-stage renal disease.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Baxter
    Sản phẩm biệt dược : Adept
  • Công ty : Baxter
    Sản phẩm biệt dược : Dextrin, Caloreen
  • Công ty : Baxter
    Sản phẩm biệt dược : Extraneal
  • Công ty :
    Sản phẩm biệt dược : Icodial
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00702
PharmGKB
http://www.pharmgkb.org/drug/PA164743096
Wikipedia
http://en.wikipedia.org/wiki/Icodextrin
RxList
http://www.rxlist.com/cgi/generic3/extraneal.htm
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