Tìm theo
Hydroxyproline
Các tên gọi khác (2) :
  • L-Hydroxyproline
  • trans-4-Hydroxy-L-proline
Thuốc Gốc
Small Molecule
CAS: 51-35-4
CTHH: C5H9NO3
PTK: 131.1299
Hydroxyproline is a neutral heterocyclic protein amino acid. It is found in collagen and as such it is common in many gelatin products. Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline is being studied as an an experimental medicine but is approved in France as a combination topical gel product called Cicactive for small, superficial wounds.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H9NO3
Phân tử khối
131.1299
Monoisotopic mass
131.058243159
InChI
InChI=1/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4?/s2
InChI Key
InChIKey=PMMYEEVYMWASQN-ACHLYQRRNA-N
IUPAC Name
(4S)-4-hydroxypyrrolidine-2-carboxylic acid
Traditional IUPAC Name
(4S)-4-hydroxypyrrolidine-2-carboxylic acid
SMILES
O[C@@H]1CNC(C1)C(O)=O
Độ tan chảy
274°C
Độ sôi
Decomposes
Độ hòa tan
Soluble in water at 0, 25, 50, and 60 °C
logP
-3.7
logS
0.57
pKa (strongest acidic)
1.64
pKa (Strongest Basic)
10.62
PSA
69.56 Å2
Refractivity
29.38 m3·mol-1
Polarizability
12.33 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
4
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
pKa
pK1′ 1.82 and pK2′ 9.65
Dược Lực Học : Hydroxyproline as well as proline and glycine are the major components of collagen. Collagen is on one of the main building blocks of connective tissue such as skin, bone, and cartilage. Thus when these tissues are damaged, hydroxyproline is necessary for repair of the damaged area.
Chỉ Định : Used in France as a combination product for the treatment of small, superficial wounds.
Liều Lượng & Cách Dùng : Gel - Topical
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08847
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C01157
Wikipedia
http://en.wikipedia.org/wiki/Hydroxyproline
... loading
... loading