Tìm theo
Huperzine B
Các tên gọi khác (2) :
  • HUB
  • HupB
Thuốc Gốc
Small Molecule
CAS: 103548-82-9
CTHH: C16H20N2O
PTK: 256.3428
Huperzine B is a novel acetylcholinesterase inhibitor.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H20N2O
Phân tử khối
256.3428
Monoisotopic mass
256.157563272
InChI
InChI=1S/C16H20N2O/c1-10-7-11-8-14-13(4-5-15(19)18-14)16(9-10)12(11)3-2-6-17-16/h4-5,7,11-12,17H,2-3,6,8-9H2,1H3,(H,18,19)
InChI Key
InChIKey=YYWGABLTRMRUIT-UHFFFAOYSA-N
IUPAC Name
16-methyl-6,14-diazatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,16-trien-5-one
Traditional IUPAC Name
16-methyl-6,14-diazatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,16-trien-5-one
SMILES
CC1=CC2CC3=C(C=CC(=O)N3)C3(C1)NCCCC23
Độ hòa tan
1.88e-01 g/l
logP
0.67
logS
-3.1
pKa (strongest acidic)
11.22
pKa (Strongest Basic)
9.77
PSA
41.13 Å2
Refractivity
78.06 m3·mol-1
Polarizability
28.43 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Huperzine B is an alkaloid derived from Huperzia serrata (which is available as an herbal product in the US). It is under investigation as an acetylcholinesterase inhibitor. Clinical trials in China have shown that huperzine B is comparably effective to the drugs currently on the market, and may even be somewhat safer in terms of side effects.
Cơ Chế Tác Dụng : Huperzine B is a novel acetylcholinesterase inhibitor. Huperzine B has been found to be an inhibitor of the enzyme acetylcholinesterase. This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease.
Chỉ Định : Under investigation for the treatment of Alzheimer's disease.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB03348
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5462442
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=12052
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C09866
ChemSpider
http://www.chemspider.com/Chemical-Structure.3505.html
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